“Ureidoglycolate dehydrogenase”的意思、由来-开放百科全书

词条

Ureidoglycolate dehydrogenase

释义

Structural studies
References

{{enzyme
| Name = ureidoglycolate dehydrogenase
| EC_number = 1.1.1.154
| CAS_number = 62213-62-1
| IUBMB_EC_number = 1/1/1/154
| GO_code = 0009040
| image =
| width =
| caption =
}}

In enzymology, an ureidoglycolate dehydrogenase ({{EC number|1.1.1.154}}) is an enzyme that catalyzes the chemical reaction

(S)-ureidoglycolate + NAD(P)⁺ oxalureate + NAD(P)H + H⁺

The 3 substrates of this enzyme are (S)-ureidoglycolate, NAD⁺, and NADP⁺, whereas its 4 products are oxalureate, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (S)-ureidoglycolate:NAD(P)⁺ oxidoreductase. This enzyme participates in purine metabolism.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1WTJ}} and {{PDB link|1XRH}}.

References

{{cite journal | vauthors = van der Drift C, van Helvoort PE, Vogels GD | year = 1971 | title = S-ureidoglycolate dehydrogenase: purification and properties | journal = Arch. Biochem. Biophys. | volume = 145 | pages = 465–9 | pmid = 4399430 | doi = 10.1016/S0003-9861(71)80006-1 | issue = 2 }}

4 : EC 1.1.1|NADPH-dependent enzymes|NADH-dependent enzymes|Enzymes of known structure

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