| 词条 | Ureidopenicillin |
| 释义 |
The ureidopenicillins are a group of penicillins which are active against Pseudomonas aeruginosa. There are three ureidopenicillins in clinical use:[1]
They are mostly ampicillin derivatives in which the amino acid side chain has been converted to a variety of cyclic ureas. It is speculated that the added side chain mimics a longer segment of the peptidoglycan chain, more than ampicillin, and thus would bind more easily to the penicillin-binding proteins. Ureidopenicillins are not resistant to beta-lactamases. They are used parenterally, and are particularly indicated in infections caused by Gram-negative bacteria. References1. ^{{cite web |url=http://www.mayoclinicproceedings.com/inside.asp?AID=2547 |title=Mayo Clinic Proceedings |format= |work= |accessdate=2008-12-26}} {{Dead link|date=October 2010|bot=H3llBot}} {{antibiotic-stub}}{{Cell wall disruptive antibiotics}} 1 : Penicillins |
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