词条 | Uridine diphosphate glucose |
释义 |
| verifiedrevid = 470620377 | ImageFile = UDP-Glucose.svg | ImageSize = | IUPACName = [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] hydrogen phosphate | OtherNames = UDP-glucose | Section1 = {{Chembox Identifiers | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 8308 | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 375951 | InChI = 1/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/t5-,6-,8-,9-,10+,11-,12-,13-,14-/m1/s1 | InChIKey = HSCJRCZFDFQWRP-JZMIEXBBBU | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/t5-,6-,8-,9-,10+,11-,12-,13-,14-/m1/s1 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = HSCJRCZFDFQWRP-JZMIEXBBSA-N | CASNo_Ref = {{cascite|correct|CAS}} | CASNo = 133-89-1 | PubChem = 8629 | IUPHAR_ligand = 1783 | ChEBI_Ref = {{ebicite|correct|EBI}} | ChEBI = 52249 | SMILES = O=P(O[C@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)CO)(O)OP(=O)(O)OC[C@H]3O[C@@H](N2/C=C\\C(=O)NC2=O)[C@H](O)[C@@H]3O | MeSHName = Uridine+Diphosphate+Glucose | Section2 = {{Chembox Properties | Formula = C15H24N2O17P2 | MolarMass = 566.302 g/mol | Appearance = | Density = | MeltingPt = | BoilingPt = | Section3 = {{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }} Uridine diphosphate glucose (uracil-diphosphate glucose, UDP-glucose) is a nucleotide sugar. It is involved in glycosyltransferase reactions in metabolism. FunctionsUDP-glucose is used in nucleotide sugar metabolism as an activated form of glucose, a substrate for enzymes called glucosyltransferases.[1] UDP-glucose is a precursor of glycogen and can be converted into UDP-galactose and UDP-glucuronic acid, which can then be used as substrates by the enzymes that make polysaccharides containing galactose and glucuronic acid. UDP-glucose can also be used as a precursor of sucrose lipopolysaccharides, and glycosphingolipids. ComponentsUDP-glucose consists of the pyrophosphate group, the pentose sugar ribose, glucose, and the nucleobase uracil. See also
References1. ^{{cite journal |vauthors=Rademacher T, Parekh R, Dwek R |title=Glycobiology |journal=Annu Rev Biochem |volume=57 |issue= |pages=785–838 |year=1988 |pmid=3052290 |doi=10.1146/annurev.bi.57.070188.004033}} {{Nucleotide sugars}}{{Fructose and galactose metabolic intermediates}}{{Purinergics}} 2 : Nucleotides|Coenzymes |
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