| 词条 | Urtoxazumab |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 470620672 | image = | type = mab | mab_type = mab | source = zu/o | target = E. coli Shiga-like toxin II B subunit | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 502496-16-4 | ATC_prefix = none | ATC_suffix = | PubChem = | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = none | C=6414 | H=9934 | N=1718 | O=2010 | S=40 | molecular_weight = 144.6 kg/mol }}Urtoxazumab is a humanized monoclonal antibody against diarrhoea caused by Escherichia coli, serotype O121. The drug is designed to bind to a toxin of this bacterium, so that it can be more easily broken down and eliminated from the body.[1][2] References1. ^International Nonproprietary Names for Pharmaceutical Substances (INN), World Health Organization. {{Monoclonals for infectious disease and toxins}}{{antiinfective-drug-stub}}{{monoclonal-antibody-stub}}2. ^{{cite journal|year=2009|last1=López|first1=EL|last2=Contrini|first2=MM|last3=Glatstein|first3=E|last4=González Ayala|first4=S|last5=Santoro|first5=R|last6=Allende|first6=D|last7=Ezcurra|first7=G|last8=Teplitz|first8=E|last9=Koyama|first9=T|last10=Matsumoto|first10=Y.|last11=Sato|first11=H.|last12=Sakai|first12=K.|last13=Hoshide|first13=S.|last14=Komoriya|first14=K.|last15=Morita|first15=T.|last16=Harning|first16=R.|last17=Brookman|first17=S.|title=Safety and Pharmacokinetics of Urtoxazumab, a Humanized Monoclonal Antibody Against Shiga-Like Toxin 2 in Healthy Adults and Pediatric STEC- Infected Patients|doi=10.1128/AAC.00343-09|journal=Antimicrobial Agents and Chemotherapy|pmid=19822704|volume=54|pages=239–243|issue=1|pmc=2798559|display-authors=8}} 2 : Monoclonal antibodies|Experimental drugs |
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