1. Structural studies

2. See also

3. References

In enzymology, a valine-tRNA ligase ({{EC number|6.1.1.9}}) is an enzyme that catalyzes the chemical reaction

ATP + L-valine + tRNAVal AMP + diphosphate + L-valyl-tRNAVal

The 3 substrates of this enzyme are ATP, L-valine, and tRNA(Val), whereas its 3 products are AMP, diphosphate, and L-valyl-tRNA(Val).

This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-valine:tRNAVal ligase (AMP-forming). Other names in common use include valyl-tRNA synthetase, valyl-transfer ribonucleate synthetase, valyl-transfer RNA synthetase, valyl-transfer ribonucleic acid synthetase, valine transfer ribonucleate ligase, and valine translase. This enzyme participates in valine, leucine and isoleucine biosynthesis and aminoacyl-trna biosynthesis.

Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1GAX}}, {{PDB link|1IVS}}, {{PDB link|1IYW}}, {{PDB link|1WK9}}, and {{PDB link|1WKA}}.

See also

• VARS

References

• {{cite journal | vauthors = Berg P, Bergmann FH, Ofengand EJ, Dieckmann M | year = 1961 | title = The enzymic synthesis of amino acyl derivatives of ribonucleic acid I. The mechanism of leucyl-, valyl-, isoleucyl- and methionyl ribonucleic acid formation | journal = J. Biol. Chem. | volume = 236 | pages = 1726–1734 }}
• {{cite journal | vauthors = Bergmann FH, Berg P, Dieckmann M | year = 1961 | title = The enzymic synthesis of amino acyl derivatives of ribonucleic acid II. The preparation of leucyl-, valyl-, isoleucyl- and methionyl ribonucleic acid synthetases from Escherichia coli | journal = J. Biol. Chem. | volume = 236 | pages = 1735–1740 }}

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