Weddington can refer to:

• Sarah Weddington, attorney in the Roe vs. Wade abortion case, former member of the Texas House of Representatives from Austin
• Susan Weddington, state chairman of the Republican Party of Texas from 1997 to 2003
• W. Carlton Weddington, a former Ohio state legislator convicted of bribery in 2012
• Weddington, Arkansas
• Weddington, North Carolina
• Weddington, Nuneaton, an area Nuneaton, Warwickshire, England
• "Weddington Street", a song by Frank Gambale from his 1985 album Brave New Guitar

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