| 释义 |
- Biography
- Scientific contributions
- Honors
- Selected publications
- Selected books
- References
- External links
{{Infobox scientist
|birth_name = Wen Hsiung Li
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| birth_date = {{Birth date and age|1942|09|22}}
| birth_place = Pingtung, Taiwan
| residence =
| citizenship = Taiwanese-American
| nationality = Taiwanese
| fields = Mathematics
Genetics
Evolutionary Biology
Genomics
| workplaces = University of Chicago
Academia Sinica
University of Texas
University of Wisconsin-Madison
| alma_mater = Brown University, Providence, RI, USA
National Central University, Taiwan
Chung-Yuang College of Science and Engineering, Taiwan
| doctoral_advisor = Wendell Fleming
| thesis_title = Mathematical Studies On Mutational Damages In Finite Populations
| thesis_url = http://search.proquest.com/docview/302674976
| thesis_year = 1972
| academic_advisors = Masatoshi Nei
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| notable_students =
| known_for = Male-Driven Evolution[1][2][3]
Molecular clock[4]
Genomics[5]
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| awards = Balzan Prize for Genetics and Evolution (2003)[6]
Mendel Medal (2009)[7]
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| website = {{URL|http://pondside.uchicago.edu/~lilab| Li Laboratory at University of Chicago}}
Wen Hsiung Li Profile at Academia Sinica
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}}Wen-Hsiung Li ({{zh|c=李文雄}}; born 1942) is a Taiwanese-American scientist working in the fields of molecular evolution, population genetics, and genomics. He is currently the James Watson Professor of Ecology and Evolution at the University of Chicago and a Principal Investigator at the Institute of Information Science and Genomics Research Center, Academia Sinica, Taiwan. BiographyLi was born in 1942 in Taiwan. In 1968 he received a M.S. in geophysics from National Central University. In 1972 he received his Ph.D in applied mathematics at Brown University in Providence, Rhode Island. From 1972 to 1973 he was a post-doctoral researcher at the University of Wisconsin Madison (genetics), working with James F. Crow. In 1973 he moved to the University of Texas, where he was appointed as a professor in 1984. Since 1998 he has been a professor at The University of Chicago. Scientific contributionsProfessor Li is best known for his studies on the molecular clock (i.e. rates and patterns of DNA sequence evolution) and on the patterns and consequences of gene duplication. In 2003, he received the international Balzan Prize for his contribution to genetics and evolutionary biology, and was elected to the National Academy of Sciences, who cited his role in "establishing theoretical foundations for molecular phylogenetics and evolutionary genomics" . He is the author of the first texts in the field of molecular evolution, Molecular Evolution and Fundamentals of Molecular Evolution (co-authored with Dan Graur), and an author on more than 200 peer-reviewed publications. Honors- Academia Sinica Taiwan, 1998
- American Academy of Arts and Sciences, 1999
- President of the “Society for Molecular Biology and Evolution”, 2000
- National Academy of Sciences, 2003
- Balzan prize 2003 for genetics and evolution (The third recipient, following Sewall Wright (1984) and John Maynard Smith (1991)).
- Inaugural HUGO/ "Chen Award" for Achievement in Human Genetic and Genomic Research, 2008
Selected publications- {{Cite journal | doi = 10.1073/pnas.1314090110| title = Assembler for de novo assembly of large genomes| journal = Proceedings of the National Academy of Sciences| volume = 110| issue = 36| pages = E3417| year = 2013| last1 = Chu | first1 = T. -C. | last2 = Lu | first2 = C. -H. | last3 = Liu | first3 = T.| last4 = Lee | first4 = G. C.| last5 = Li | first5 = W. -H. | last6 = Shih | first6 = A. C. -C. | pmc = 3767511}}
- {{Cite journal | doi = 10.1038/nature01198| pmid = 12511954| title = Role of duplicate genes in genetic robustness against null mutations| journal = Nature| volume = 421| issue = 6918| pages = 63–6| year = 2003| last1 = Gu | first1 = Z. | last2 = Steinmetz | first2 = L. M. | last3 = Gu | first3 = X. | last4 = Scharfe | first4 = C. | last5 = Davis | first5 = R. W. | last6 = Li | first6 = W. H. }}
- {{Cite journal | doi = 10.1038/416624a| pmid = 11948348| title = Strong male-driven evolution of DNA sequences in humans and apes| journal = Nature| volume = 416| issue = 6881| pages = 624–6| year = 2002| last1 = Makova | first1 = K. D. | last2 = Li | first2 = W. H. }}
- {{Cite journal | doi = 10.1038/35057039| pmid = 11237007| title = Evolutionary analyses of the human genome| journal = Nature| volume = 409| issue = 6822| pages = 847–9| year = 2001| last1 = Li | first1 = W. H. | last2 = Gu | first2 = Z. | last3 = Wang | first3 = H. | last4 = Nekrutenko | first4 = A. }}
- {{Cite journal| doi = 10.1038/46947| pmid = 10573416| title = Vision: Trichromatic vision in prosimians| year = 1999| last1 = Tan | first1 = Y. | journal = Nature| volume = 402| issue = 6757| pages = 36| last2 = Li | first2 = W. H. }}
- {{Cite journal | doi = 10.1126/science.7652574| pmid = 7652574| title = Adaptive evolution of color vision genes in higher primates| journal = Science| volume = 269| issue = 5228| pages = 1265–7| year = 1995| last1 = Shyue | first1 = S.| last2 = Hewett-Emmett | first2 = D.| last3 = Sperling | first3 = H.| last4 = Hunt | first4 = D.| last5 = Bowmaker | first5 = J.| last6 = Mollon | first6 = J.| last7 = Li | first7 = W.H.}}
- {{Cite journal | doi = 10.1038/362745a0| pmid = 8469284| title = Male-driven evolution of DNA sequences| journal = Nature| volume = 362| issue = 6422| pages = 745–7| year = 1993| last1 = Shimmin | first1 = L. C. | last2 = Chang | first2 = B. H. J. | last3 = Li | first3 = W. H. }}
- {{Cite journal | doi = 10.1038/351649a0| pmid = 2052090| title = Is the guinea-pig a rodent?| journal = Nature| volume = 351| issue = 6328| pages = 649–52| year = 1991| last1 = Graur | first1 = D. | last2 = Hide | first2 = W. A. | last3 = Li | first3 = W. H. }}
- {{Cite journal | doi = 10.1038/354114e0| title = Neutral mutation hypothesis test| journal = Nature| volume = 354| issue = 6349| pages = 114| year = 1991| last1 = Graur | first1 = D. A. N. | last2 = Li | first2 = W.H. }}
- {{Cite journal | doi = 10.1038/337283a0| pmid = 2911369| title = Mutation rates differ among regions of the mammalian genome| journal = Nature| volume = 337| issue = 6204| pages = 283–5| year = 1989| last1 = Wolfe | first1 = K. H. | last2 = Sharp | first2 = P. M. | last3 = Li | first3 = W. H. }}
- {{Cite journal | doi = 10.1038/339145a0| pmid = 2497353| title = Phylogenetic analysis based on rRNA sequences supports the archaebacterial rather than the eocyte tree| journal = Nature| volume = 339| issue = 6220| pages = 145–7| year = 1989| last1 = Gouy | first1 = M. | last2 = Li | first2 = W. H. }}
- {{Cite journal | doi = 10.1126/science.2683084| pmid = 2683084| title = Chromosomal location and evolutionary rate variation in enterobacterial genes| journal = Science| volume = 246| issue = 4931| pages = 808–10| year = 1989| last1 = Sharp | first1 = P.| last2 = Shields | first2 = D.| last3 = Wolfe | first3 = K.| last4 = Li | first4 = W.H.}}
- {{Cite journal | doi = 10.1038/336315a0| pmid = 3194016| title = Understanding the origins of AIDS viruses| journal = Nature| volume = 336| issue = 6197| pages = 315| year = 1988| last1 = Sharp | first1 = P. M. | last2 = Li | first2 = W.H. }}
- {{Cite journal | doi = 10.1038/326093a0| pmid = 3102974| title = The molecular clock runs more slowly in man than in apes and monkeys| journal = Nature| volume = 326| issue = 6108| pages = 93–6| year = 1987| last1 = Li | first1 = W. H. | last2 = Tanimura | first2 = M. }}
- {{Cite journal | doi = 10.1038/292237a0| pmid = 7254315| title = Pseudogenes as a paradigm of neutral evolution| journal = Nature| volume = 292| issue = 5820| pages = 237–9| year = 1981| last1 = Li | first1 = W. H. | last2 = Gojobori | first2 = T. | last3 = Nei | first3 = M. }}
- {{Cite journal | doi = 10.1073/pnas.76.10.5269| title = Mathematical model for studying genetic variation in terms of restriction endonucleases| journal = Proceedings of the National Academy of Sciences| volume = 76| issue = 10| pages = 5269–73| year = 1979| last1 = Nei | first1 = M.| last2 = Li | first2 = W. H. | pmid=291943 | pmc=413122}}
Selected books- {{cite book |author=Li, W.-H. |year=2006 |title= Molecular Evolution |publisher=Sinauer|isbn=0-87893-480-4}}
- {{cite book |author1=Dan Graur |author2= Wen-Hsiung Li |year=2000 |title=Fundamentals of Molecular Evolution: Second Edition. |publisher=Sinauer Associates, Inc.}}
References1. ^{{Cite journal | doi = 10.1038/362745a0| pmid = 8469284| title = Male-driven evolution of DNA sequences| journal = Nature| volume = 362| issue = 6422| pages = 745–7| year = 1993| last1 = Shimmin | first1 = L. C. | last2 = Chang | first2 = B. H. J. | last3 = Li | first3 = W. H. }}
2. ^{{Cite journal | doi = 10.1038/416624a| pmid = 11948348| title = Strong male-driven evolution of DNA sequences in humans and apes| journal = Nature| volume = 416| issue = 6881| pages = 624–6| year = 2002| last1 = Makova | first1 = K. D. | last2 = Li | first2 = W. H. }}
3. ^{{cite web|title=Males' DNA propels evolution, study says|url=http://articles.chicagotribune.com/2002-04-11/news/0204110283_1_mutation-y-chromosome-evolutionary-change|publisher=Chicago Tribune|accessdate=June 1, 2014}}
4. ^{{Cite journal | doi = 10.1126/science.3983640| title = Molecular clocks scrutinized| journal = Science| volume = 228| issue = 4699| pages = 571| year = 1985| last1 = Lewin | first1 = R. }}
5. ^{{Cite journal | doi = 10.1038/35057039| pmid = 11237007| title = Evolutionary analyses of the human genome| journal = Nature| volume = 409| issue = 6822| pages = 847–9| year = 2001| last1 = Li | first1 = W. H. | last2 = Gu | first2 = Z. | last3 = Wang | first3 = H. | last4 = Nekrutenko | first4 = A. }}
6. ^{{cite web|title=Balzan Prize for Genetics and Evolution|url=http://www.balzan.org/en/prizewinners/wen-hsiung-li|work=International Balzan Prize Foundation website|publisher=International Balzan Prize Foundation|accessdate=February 8, 2014}}
7. ^{{cite web|title=Mendel Medal|url=http://www.genetics.org.uk/Prizes/MendelMedal.aspx/|work=The Genetics Society website|publisher=The Genetics Society|accessdate=February 8, 2014}}
External links- Official research profile
- Lab web site
- National Academy of Sciences citation
- Balzan Foundation profile
- Academia Sinica website reference for the HUGO/ "Chen Award" 2008
{{Authority control}}{{DEFAULTSORT:Li, Wen-Hsiung}} 12 : 1942 births|American scientists of Taiwanese descent|Evolutionary biologists|Living people|Theoretical biologists|Population geneticists|University of Chicago faculty|Members of Academia Sinica|Members of the United States National Academy of Sciences|21st-century biologists|American geneticists|Taiwanese biologists |