| 词条 | Friedrich Sertürner |
| 释义 |
|name = Friedrich Sertüner |image =Friedrich Wilhelm Adam Sertuerner.jpg |image_size =150px |caption = Friedrich Wilhelm Adam Sertüner |birth_date = 19 June 1783 |birth_place = Neuhaus |death_date = {{death date and age|df=y|1841|2|20|1783|6|19}} |death_place = Hamelin |residence = |citizenship = |nationality = German |ethnicity = |field = Pharmacology, Alkaloid chemistry |work_institutions = |alma_mater = |doctoral_advisor = |doctoral_students = |known_for = discovering morphine |author_abbrev_bot = |author_abbrev_zoo = |influences = |influenced = |prizes = |religion = |footnotes = |signature = }}Friedrich Wilhelm Adam Sertüner (19 June 1783 – 20 February 1841) was a German pharmacist and a pioneer of Alkaloid chemistry. He is best known for his discovery of morphine in 1804.[1][1][2] BiographyFriedrich Wilhelm Adam Sertüner was born to Joseph Simon Serdinner and Marie Therese Brockmann on 19 June 1783, in Neuhaus, North Rhine-Westphalia (now part of Paderborn). After his parents died, he became a pharmacist's apprentice in Paderborn.[1] Sertüner was the first to isolate morphine from opium. He called the isolated alkaloid "morphium" after the Greek god of dreams, Morpheus. He published a comprehensive paper on its isolation, crystallization, crystal structure, and pharmacological properties, which he studied first in stray dogs and then in self-experiments.[3] Morphine was not only the first alkaloid to be extracted from opium, but the first ever alkaloid to be isolated from any plant. Thus Sertüner became the first person to isolate the active ingredient associated with a medicinal plant or herb.[4][5][1] The branch of science that he originated has since become known as alkaloid chemistry.[1] In 1806 Sertüner moved to Einbeck, working as a pharmacists' assistant. In 1809, Sertüner opened the first pharmacy he owned, in Einbeck. He continued to investigate the effects of morphine.[1] After the publication of his paper "Ueber das Morphium als Hauptbestandteil des Opiums" in 1817, his work on morphine became more widely known and morphine became more widely used.[6] In 1822, Sertüner bought the main pharmacy in Hamelin (Rathaus Apotheke), where he worked until his death on February 20, 1841. He was buried in Einbeck.[1] RecognitionIn 1817 Sertüner was awarded an honorary doctorate from Jena University.[1] In 1831, Sertüner received the Montyon Prize and the title ‘Benefactor of Humanity’.[1] References1. ^1 2 3 4 5 6 7 {{cite journal |last1=Krishnamurti |first1=Chandrasekhar |last2=Rao |first2=SSCChakra |title=The isolation of morphine by Sertuner |journal=Indian Journal of Anaesthesia |date=2016 |volume=60 |issue=11 |pages=861–862 |doi=10.4103/0019-5049.193696 |pmid=27942064 |pmc=5125194 }} 2. ^{{cite web |first=Klaus |last=Meyer |year=2004 |title=Dem Morphin auf der Spur |language=German |url=http://www.pharmazeutische-zeitung.de/index.php?id=26551 |accessdate=8 September 2009 |work=Pharmazeutischen Zeitung |publisher=GOVI-Verlag}} 3. ^Atanasov AG, Waltenberger B, Pferschy-Wenzig EM, Linder T, Wawrosch C, Uhrin P, Temml V, Wang L, Schwaiger S, Heiss EH, Rollinger JM, Schuster D, Breuss JM, Bochkov V, Mihovilovic MD, Kopp B, Bauer R, Dirsch VM, Stuppner H. Discovery and resupply of pharmacologically active plant-derived natural products: A review. Biotechnol Adv. 2015 Aug 15., {{PMID|26281720}} 4. ^1 {{cite journal |last1=Rinde |first1=Meir |title=Opioids' Devastating Return |url=https://www.sciencehistory.org/distillations/magazine/opioids-devastating-return |journal=Distillations |date=2018|volume=4 |issue=2 |pages=12–23 |accessdate=August 23, 2018 }} 5. ^{{cite book |last1=Booth |first1=Martin |title=Opium : a history |publisher=St. Martin's Press |isbn=978-0312206673 |edition=1st U.S.|date=1999-06-12 }} 6. ^{{cite journal |last1=Sertüner |first1=F. W. |title=Über das Morphium, eine neue salzfähige Grundlage, und die Mekonsäure, als Hauptbestandteile des Opiums |journal=Annalen der Physik |date=1817 |volume=25 |pages=56–90}} Further reading
6 : 1783 births|1841 deaths|People from Paderborn|German chemists|German pharmacists|Morphine |
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