| 词条 | YdaO/yuaA leader |
| 释义 |
| Name = ydaO/yuaA leader | image = RF00379.jpg | width = | caption = Predicted secondary structure and sequence conservation of ydaO-yuaA | Symbol = ydaO-yuaA | AltSymbols = | Rfam = RF00379 | miRBase = | miRBase_family = | RNA_type = Cis-reg; riboswitch | Tax_domain = Bacteria | GO = | SO = {{SO|0000233}} | CAS_number = | EntrezGene = | HGNCid = | OMIM = | PDB = | RefSeq = | Chromosome = | Arm = | Band = | LocusSupplementaryData = }} The YdaO/YuaA leader (now called the cyclic di-AMP riboswitch) is a conserved RNA structure found upstream of the ydaO and yuaA genes in Bacillus subtilis and related genes in other bacteria. Its secondary structure and gene associations were predicted by bioinformatics.[1] These RNAs function as riboswitches, and sense the signaling molecule cyclic di-AMP.[2] The interaction between the riboswitch and c-di-AMP has been revealed in atomic-resolution structures.[3][4][5] References1. ^{{cite journal |vauthors=Barrick JE, Corbino KA, Winkler WC, Nahvi A, Mandal M, Collins J, Lee M, Roth A, Sudarsan N, Jona I, Wickiser JK, Breaker RR |title=New RNA motifs suggest an expanded scope for riboswitches in bacterial genetic control |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue=17 |pages=6421–6 |year=2004 |pmid=15096624 |pmc=404060 |doi=10.1073/pnas.0308014101 |url=}} 2. ^{{cite journal |vauthors=Nelson JW, Sudarsan N, Furukawa K, Weinberg Z, Wang JX, Breaker RR |title=Riboswitches in eubacteria sense the second messenger c-di-AMP |journal=Nat. Chem. Biol. |volume=9 |issue=12 |pages=834–9 |year=2013 |pmid=24141192 |pmc=3830699 |doi=10.1038/nchembio.1363 |url=}} 3. ^{{cite journal |vauthors=Gao A, Serganov A |title=Structural insights into recognition of c-di-AMP by the ydaO riboswitch |journal=Nat. Chem. Biol. |volume=10 |issue=9 |pages=787–92 |year=2014 |pmid=25086507 |pmc=4294798 |doi=10.1038/nchembio.1607 |url=}} 4. ^{{cite journal |vauthors=Ren A, Patel DJ |title=c-di-AMP binds the ydaO riboswitch in two pseudo-symmetry-related pockets |journal=Nat. Chem. Biol. |volume=10 |issue=9 |pages=780–6 |year=2014 |pmid=25086509 |pmc=4217635 |doi=10.1038/nchembio.1606 |url=}} 5. ^{{cite journal |vauthors=Jones CP, Ferré-D'Amaré AR |title=Crystal structure of a c-di-AMP riboswitch reveals an internally pseudo-dimeric RNA |journal=EMBO J. |volume=33 |issue=22 |pages=2692–703 |year=2014 |pmid=25271255 |pmc=4282576 |doi=10.15252/embj.201489209 |url=}} External links
1 : Cis-regulatory RNA elements |
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