| 词条 | Zinc finger FYVE domain-containing protein 9 |
| 释义 |
Zinc finger FYVE domain-containing protein 9 or SARA (SMAD anchor for receptor activation) is a protein that in humans is encoded by the ZFYVE9 gene.[1] SARA contains a double zinc finger (FYVE domain). SARA is an anchoring protein involved in TGF beta signaling. It binds to the MH2 domain of the R-SMADs SMAD2 and SMAD3 as well as the type I TGF beta receptors.[2] It facilitates the phosphorylation of the R-SMAD, which subsequently dissociates from SARA and the receptor and binds a coSMAD where they enter the nucleus as transcription factors. References1. ^{{cite journal | vauthors = Tsukazaki T, Chiang TA, Davison AF, Attisano L, Wrana JL | title = SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor | journal = Cell | volume = 95 | issue = 6 | pages = 779–791 |date=December 1998 | pmid = 9865696 | doi =10.1016/S0092-8674(00)81701-8 | url = | issn = }} {{TGF beta signaling}}{{gene-1-stub}}2. ^{{cite journal | vauthors = Lin HK, Bergmann S, Pandolfi PP | title = Cytoplasmic PML function in TGF-beta signalling | journal = Nature | volume = 431 | issue = 7005 | pages = 205–211 |date=September 2004 | pmid = 15356634 | doi = 10.1038/nature02783 | url = | issn = }} 2 : Developmental genes and proteins|FYVE domain |
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