Zygaena is a genus of moths in the family Zygaenidae.

Zygaena may also refer to:

• Sphyrna zygaena, the smooth hammerhead shark
• Zygaena dissimilis and Zygaena mokarran, synonyms of the great hammerhead shark, Sphyrna mokarran
• Zygaena blochii, Zygaena laticeps, Zygaena latycephala, synonyms of the winghead shark, Eusphyra blochii
• Zygaena lewini, Zygaena erythraea, obsolete names for the scalloped hammerhead shark, Sphyrna lewini
• Zygocranchia zygaena, a synonym for Galiteuthis armata, the armed cranch squid

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