| 词条 | Zylofuramine |
| 释义 |
| verifiedrevid = 443223982 | IUPAC_name = (1R)-N-Ethyl-2-phenyl-1-[(2R)-tetrahydrofuran-2-yl]ethanamine | image = Zylofuramine.svg | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number = 3563-92-6 | ATC_prefix = none | ATC_suffix = | PubChem = 71129 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 64277 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 8N66VC535R | C=14 | H=21 | N=1 | O=1 | smiles = O2[C@@H]([C@H](NCC)Cc1ccccc1)CCC2 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C14H21NO/c1-2-15-13(14-9-6-10-16-14)11-12-7-4-3-5-8-12/h3-5,7-8,13-15H,2,6,9-11H2,1H3/t13-,14-/m1/s1 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = DOFCLOLKFGSRTG-ZIAGYGMSSA-N }}Zylofuramine[1] is a stimulant drug. It was developed in 1961,[2][3] and was intended for use as an appetite suppressant and for the treatment of senile dementia in the elderly, but there is little information about it and it does not appear to have ever been marketed.[4] Its chemical structure has a similarity to other N-ethyl substituted stimulant drugs such as ethylamphetamine. References1. ^{{ cite patent | country = US | status = patent | number = 3091621 | inventor = Clarke, R. L. | gdate = 1963-05-28 | assign1 = Sterling Drugs | title = Alpha-Aryl or Aralkyl Tetrahydrofurfurylamines }} {{Stimulants}}{{Anorectics}}{{Monoamine releasing agents}}{{Phenethylamines}}{{nervous-system-drug-stub}}2. ^{{Cite journal | last1 = Clarke | first1 = R. L. | last2 = Harris | first2 = L. S. | title = α-Benzyltetrahydrofurfurylamines -- A New Series of Psychomotor Stimulants. I | journal = Journal of Medicinal Chemistry | volume = 5| issue = 1 | pages = 77–95 | year = 1962 | doi = 10.1021/jm01236a010| pmid = 14046619}} 3. ^{{Cite journal | last1 = Clarke | first1 = R. L. | last2 = Tullar | first2 = B. F. | last3 = Harris | first3 = L. S. | title = α-Benzyltetrahydrofurfurylamines -- A New Series of Psychomotor Stimulants. II. Resolution of Isomers | journal = Journal of Medicinal Chemistry | volume = 5| issue = 2| pages = 362–372 | year = 1962 | doi = 10.1021/jm01237a014| pmid = 14051912}} 4. ^{{ cite journal |author1=Harris, L. S. |author2=Clarke, R. L. |author3=Dembinski, J. R. | title = α-Benzyltetrahydrofurfurylamines -- A New Series of Psychomotor Stimulants. III. The Pharmacology of D-Threo α-Benzyl-N-Ethyltetrahydrofurfurylamine (Zylofuramine) | journal = Archives Internationales de Pharmacodynamie et de Thérapie | year = 1963 | volume = 146 | pages = 392–405 | pmid = 14099588 }} 4 : Stimulants|Tetrahydrofurans|Phenethylamines|Norepinephrine-dopamine releasing agents |
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