| 词条 | Α-Methylacetylfentanyl |
| 释义 |
| drug_name = α-Methylacetylfentanyl | verifiedrevid = 443661432 | IUPAC_name = N-Phenyl-N-[1-(1-phenylpropan-2-yl)-4-piperidyl]acetamide | image = Alphamethylacetylfentanyl.svg | width = 200px | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = Schedule I | legal_UK = Class A | legal_US = Schedule I | legal_DE = Anlage I | routes_of_administration = | bioavailability = | protein_bound = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|CAS}} | CAS_number = 101860-00-8 | ATC_prefix = none | ATC_suffix = | PubChem = 62307 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = DB01532 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 56102 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 0O1GKW2BQO | C=22 | H=28 | N=2 | O=1 | molecular_weight = 336.471 g/mol | smiles = O=C(N(c1ccccc1)C3CCN(C(Cc2ccccc2)C)CC3)C | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C22H28N2O/c1-18(17-20-9-5-3-6-10-20)23-15-13-22(14-16-23)24(19(2)25)21-11-7-4-8-12-21/h3-12,18,22H,13-17H2,1-2H3 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = OKTLVZBUKMRPLL-UHFFFAOYSA-N | synonyms = α-methylacetylfentanyl, acetyl-α-methylfentanyl }} α-Methylacetylfentanyl (or alphamethylacetylfentanyl) is an opioid analgesic that is an analog of fentanyl. It is a Schedule I controlled substance in the United States, with a DEA ACSCN of 9815. α-Methylacetylfentanyl was sold briefly on the black market in the early 1980s, before the introduction of the Federal Analog Act which for the first time attempted to control entire families of drugs based on their structural similarity rather than scheduling each drug individually as they appeared.[1] α-Methylacetylfentanyl is made with the same synthetic route as α-methylfentanyl, but by substituting the relatively common acetic anhydride for the more difficult to obtain chemical propionic anhydride in the synthesis. α-Methylacetylfentanyl has similar effects to fentanyl.{{medcn|date=August 2013}} Side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening. Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear.[2] The 2013 DEA production quota for acetyl-alpha-methylfentanyl is 2 grammes.[3] References1. ^{{cite journal | author = Henderson GL | title = Designer Drugs: Past History and Future Prospects | journal = Journal of Forensic Sciences | year = 1988 | volume = 33 | issue = 2 | pages = 569–575 | pmid = 3286815}} {{Opioidergics}}{{DEFAULTSORT:Methylacetylfentanyl, alpha-}}{{analgesic-stub}}2. ^{{cite journal | url=http://www.ijdp.org/article/S0955-3959%2815%2900097-3/abstract | title=Fentanyls: Are we missing the signs? Highly potent and on the rise in Europe. | author=Jane Mounteney | author2=Isabelle Giraudon | author3=Gleb Denissov | author4=Paul Griffiths | journal=The International Journal of Drug Policy | date=July 2015 | volume=26 | issue=7 | pages=626–631 | doi=10.1016/j.drugpo.2015.04.003 | pmid=25976511}} 3. ^http://www.deadiversion.usdoj.gov/fed_regs/quotas/2013/fr0620.htm 4 : Synthetic opioids|Piperidines|Acetanilides|Mu-opioid agonists |
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