| 词条 | 15,16-Dihydroxy-alpha-eleostearic acid |
| 释义 |
| verifiedrevid = 406641642 | Name = 15,16-Dihydroxy-α-eleostearic acid | ImageFile = 15,16-Dihydroxy-alpha-eleostearic acid.svg | ImageSize = 200px | ImageAlt = | IUPACName = (9Z,11E,13E)-15,16-Dihydroxyoctadeca-9,11,13-trienoic acid | OtherNames = |Section1={{Chembox Identifiers | CASNo = 1083078-83-4 | CASNo_Ref = {{cascite|correct|CAS}} | PubChem = 25156647 | ChemSpiderID = 57558074 | StdInChI=1S/C18H30O4/c1-2-16(19)17(20)14-12-10-8-6-4-3-5-7-9-11-13-15-18(21)22/h4,6,8,10,12,14,16-17,19-20H,2-3,5,7,9,11,13,15H2,1H3,(H,21,22)/b6-4-,10-8+,14-12+ | StdInChIKey = OBMDTPZEEDLBKM-ZMLXCLEUSA-N | SMILES = OC(CCCCCCC/C=C\\C=C\\C=C\\C(O)C(O)CC)=O}} |Section2={{Chembox Properties | C=18 | H=30 | O=4 | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = }} |Section3={{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }} }} 15,16-Dihydroxy-α-eleostearic acid, or 15,16-Dihydroxy-(9Z,11E,13E)-9,11,13-octadecatrienoic acid, is an organic compound with formula {{chem|C|18|H|30|O|4}}, or H3C-CH2-(-CH(OH)-)2(-CH=CH-)3-(-CH2-)7-(C=O)OH. It can be seen as derived from α-eleostearic acid by the replacement of two hydrogen atoms by two hydroxyl (OH) groups. The compound is found in the pulp and seeds of bitter melons (the fruits of Momordica charantia). It has been found to induce apoptosis in HL60 leukemia cells in vitro at a concentration of 160 μM, although it is less potent in this regard than the unsubstituted α-eleostearic acid (also found in the seed oil). While α-eleostearic acid has been found to prevent carcinogenesis in rats, this derivative does not seem to have that effect.[1] The compound can be extracted from the fruit with ethanol, and is soluble in ethyl acetate but not in water or acetone. See also
References1. ^Masuko Kobori, Mayumi Ohnishi-Kameyama, Yukari Akimoto, Chizuko Yukizaki and Mitsuru Yoshida (2008) α-Eleostearic Acid and Its Dihydroxy Derivative Are MajorApoptosis-Inducing Components of Bitter Gourd. Journal of Agricultural and Food Chemistry, volume 56, issue 22, pages 10515–10520. {{doi|10.1021/jf8020877}} {{DEFAULTSORT:Dihydroxy-alpha-eleostearic acid, 15,16-}} 1 : Fatty acids |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。