| 词条 | 17-Phenylandrostenol |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 477209277 | IUPAC_name = (3R,5S,8R,9S,10S,13S,14S)-10,13-dimethyl-17-phenyl- 2,3,4,5,6,7,8,9,11,12,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol | image = 17-Phenylandrostenol.png | width = 200 | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 694438-95-4 | ATC_prefix = | ATC_suffix = | ATC_supplemental = | PubChem = 25068278 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 21475142 | chemical_formula = | C=25 | H=34 | O=1 | molecular_weight = 350.535 g/mol | smiles = C[C@]12CC[C@H](C[C@@H]1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC=C4C5=CC=CC=C5)C)O | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C25H34O/c1-24-14-12-19(26)16-18(24)8-9-20-22-11-10-21(17-6-4-3-5-7-17)25(22,2)15-13-23(20)24/h3-7,10,18-20,22-23,26H,8-9,11-16H2,1-2H3/t18-,19+,20-,22-,23-,24-,25+/m0/s1 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = SINAMTXBCYKFDL-WBJZGETLSA-N | synonyms = (3α,5α)-17-Phenyl-androst-16-en-3-ol }}17-Phenylandrostenol (17-PA), or (3α,5α)-17-phenylandrost-16-en-3-ol, is a steroid drug which binds to GABAA receptors. It acts as an antagonist against the sedative effects of neuroactive steroids, but has little effect when administered by itself, and does not block the effects of benzodiazepines or barbiturates.[1][2] Chemistry{{See also|List of neurosteroids}}See also
References1. ^{{cite journal |vauthors=Mennerick S, He Y, Jiang X, Manion BD, Wang M, Shute A, Benz A, Evers AS, Covey DF, Zorumski CF |title=Selective antagonism of 5alpha-reduced neurosteroid effects at GABA(A) receptors |journal=Molecular Pharmacology |volume=65 |issue=5 |pages=1191–7 |date=May 2004 |pmid=15102947 |doi=10.1124/mol.65.5.1191 |url=}} {{GABAergics}}{{DEFAULTSORT:Phenylandrostenol, 17-}}{{steroid-stub}}2. ^{{cite journal |vauthors=Kelley SP, Alan JK, O'Buckley TK, Mennerick S, Krishnan K, Covey DF, Leslie Morrow A |title=Antagonism of neurosteroid modulation of native γ-aminobutyric acid receptors by (3α,5α)-17-phenylandrost-16-en-3-ol |journal=European Journal of Pharmacology |volume=572 |issue=2–3 |pages=94–101 |date=October 2007 |pmid=17658511 |pmc=2098702 |doi=10.1016/j.ejphar.2007.06.028 |url=}} 3 : Androstanes|GABAA receptor negative allosteric modulators|Neurosteroids |
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