| 词条 | 1-Octacosanol |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 477208352 | ImageFile=1-Octacosanol-folded.svg | ImageSize=200px | IUPACName=Octacosan-1-ol | OtherNames=n-Octacosanol; Octacosyl alcohol; Octanosol; Montanyl alcohol; Cluytyl alcohol |Section1={{Chembox Identifiers | KEGG = C08387 | KEGG_Ref = {{keggcite|correct|kegg}} | InChI = 1/C28H58O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-27-28-29/h29H,2-28H2,1H3 | InChIKey = CNNRPFQICPFDPO-UHFFFAOYAC | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C28H58O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-27-28-29/h29H,2-28H2,1H3 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = CNNRPFQICPFDPO-UHFFFAOYSA-N | CASNo=557-61-9 | CASNo_Ref = {{cascite|changed|??}} | PubChem=68406 | SMILES = OCCCCCCCCCCCCCCCCCCCCCCCCCCCC | ChemSpiderID = 61689 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | UNII = 81I2215OVK | UNII_Ref = {{fdacite|correct|FDA}} | ChEBI = 28243 | ChEBI_Ref = {{ebicite|correct|EBI}} | MeSHName=1-octacosanol |Section2={{Chembox Properties | C=28 | H=58 | O=1 | Appearance= | Density= | MeltingPtC=83 | BoilingPt= | Solubility= |Section3={{Chembox Hazards | MainHazards= | FlashPt= | AutoignitionPt = }}1-Octacosanol{{Pronunciation-needed}} (also known as n-octacosanol, octacosyl alcohol, cluytyl{{Pronunciation-needed}} alcohol, montanyl{{Pronunciation-needed}} alcohol) is a straight-chain aliphatic 28-carbon primary fatty alcohol that is common in the epicuticular waxes of plants, including the leaves of many species of Eucalyptus, of most forage and cereal grasses, of Acacia, Trifolium, Pisum and many other legume genera among many others, sometimes as the major wax constituent.[1] Octacosanol also occurs in wheat germ.[2] ChemistryOctacosanol is insoluble in water but freely soluble in low molecular-weight alkanes and in chloroform. Biological effectsOctacosanol is the main component in the mixture policosanol.[3] Octacosanol has been subject to preliminary study for its potential benefit for patients with Parkinson's disease.[4][5] Studies have also found that octacosanol may inhibit the production of cholesterol.[3] In mice, octacosanol reduces stress and restores stress-affected sleep back to normal.[6] References1. ^EA Baker (1982) Chemistry and morphology of plant epicuticular waxes. pp139-165. In "The Plant Cuticle". edited by DF Cutler, KL Alvin and CE Price. Academic Press, London. {{ISBN|0-12-199920-3}} {{Alcohols}}{{DEFAULTSORT:Octacosanol, 1-}}2. ^{{cite web |title=Octacosanol |work=Natural Products (Professional) |publisher=drugs.com |url=https://www.drugs.com/npp/octacosanol.html |quote=isolated from wheat germ oil or other plants |accessdate=9 July 2009 |archiveurl=https://web.archive.org/web/20090603230755/http://www.drugs.com/npp/octacosanol.html |archivedate=3 June 2009 |deadurl=no |df=dmy }} 3. ^1 {{cite journal | doi = 10.1016/S0899-9007(02)00869-9 | title = Octacosanol in human health | year = 2003 | last1 = Taylor | first1 = Johanna C | last2 = Rapport | first2 = Lisa | last3 = Lockwood | first3 = G.Brian | journal = Nutrition | volume = 19 | issue = 2 | pages = 192–5 | pmid = 12591561}} 4. ^{{cite journal | pmid = 6395790 | year = 1984 | last1 = Snider | first1 = SR | title = Octacosanol in parkinsonism | volume = 16 | issue = 6 | pages = 723 | doi = 10.1002/ana.410160615 | journal = Annals of Neurology}} 5. ^{{cite journal | pmid = 20581854 | year = 2010 | last1 = Wang | first1 = T | last2 = Liu | first2 = YY | last3 = Wang | first3 = X | last4 = Yang | first4 = N | last5 = Zhu | first5 = HB | last6 = Zuo | first6 = PP | title = Protective effects of octacosanol on 6-hydroxydopamine-induced Parkinsonism in rats via regulation of ProNGF and NGF signaling | volume = 31 | issue = 7 | pages = 765–74 | doi = 10.1038/aps.2010.69 | journal = Acta pharmacologica Sinica| pmc = 4007727 }} 6. ^{{cite journal|last1 = Kaushik | first1 = MK | last2 = Aritake | first2 = K | last3 = Takeuchi | first3 = A | last4 = Yanagisawa | first4 = M | last5 = Urade | first5 = Y|title=Octacosanol restores stress-affected sleep in mice by alleviating stress|journal=Scientific Reports|date=21 August 2017|volume=7|doi=10.1038/s41598-017-08874-2|url=https://www.nature.com/articles/s41598-017-08874-2|accessdate=25 October 2017}} 3 : Fatty alcohols|Primary alcohols|Alkanols |
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