“2-(1-Hexyloxyethyl)-2-devinyl pyropheophorbide-a”的意思、由来-开放百科全书

词条

2-(1-Hexyloxyethyl)-2-devinyl pyropheophorbide-a

释义

Clinical trials
References
External links

{{chembox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 477198133
| ImageFile=Photochlor.png
| ImageSize=200px
| IUPACName=
| OtherNames=Photochlor
|Section1={{Chembox Identifiers
| Abbreviations = HPPH
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 4589621
| InChI = 1/C39H48N4O4/c1-8-10-11-12-15-47-24(7)36-22(5)30-17-29-21(4)26(13-14-35(45)46)38(42-29)27-16-34(44)37-23(6)31(43-39(27)37)18-32-25(9-2)20(3)28(40-32)19-33(36)41-30/h17-19,21,24,26,40-41H,8-16H2,1-7H3,(H,45,46)/b28-19-,29-17-,30-17-,31-18-,32-18-,33-19-,38-27-/t21-,24?,26-/m0/s1
| InChIKey = ODJVLHDVEGAIAW-NMWXTPPCBI
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C39H48N4O4/c1-8-10-11-12-15-47-24(7)36-22(5)30-17-29-21(4)26(13-14-35(45)46)38(42-29)27-16-34(44)37-23(6)31(43-39(27)37)18-32-25(9-2)20(3)28(40-32)19-33(36)41-30/h17-19,21,24,26,40-41H,8-16H2,1-7H3,(H,45,46)/b28-19-,29-17-,30-17-,31-18-,32-18-,33-19-,38-27-/t21-,24?,26-/m0/s1
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = ODJVLHDVEGAIAW-NMWXTPPCSA-N
| CASNo_Ref = {{cascite|changed|??}}
| CASNo=149402-51-7
| PubChem=5488034
| SMILES=CCCCCCOC(C)C1=C2C=C3C(=C(C(=CC4=NC5=C(CC(=O)C5=C4C)C6=NC(=CC(=C1C)N2)[C@H]([C@@H]6CCC(=O)O)C)N3)CC)C
|Section2={{Chembox Properties
| C=39 | H=48 | N=4 | O=4
| Appearance=
| Density=
| MeltingPt=
| BoilingPt=
| Solubility=
|Section3={{Chembox Hazards
| MainHazards=
| FlashPt=
| AutoignitionPt =
}}2-(1-Hexyloxyethyl)-2-devinyl pyropheophorbide-a (HPPH) is a photosensitiser chemical that is used in photodynamic therapy.^[1]

It is being developed under the brand name Photochlor.

Clinical trials

A phase I/II clinical trial started in 1997 for esophageal cancer.^[2]

A phase II trial for non-small cell lung cancer is due to run from 2007 to 2011.^[3]

References

1. ^{{cite journal | pmid = 11891727 | year = 2001 | last1 = Lobel | first1 = J | last2 = MacDonald | first2 = IJ | last3 = Ciesielski | first3 = MJ | last4 = Barone | first4 = T | last5 = Potter | first5 = WR | last6 = Pollina | first6 = J | last7 = Plunkett | first7 = RJ | last8 = Fenstermaker | first8 = RA | last9 = Dougherty | first9 = TJ | title = 2-1-hexyloxyethyl-2-devinyl pyropheophorbide-a (HPPH) in a nude rat glioma model: implications for photodynamic therapy | volume = 29 | issue = 5 | pages = 397–405 | journal = Lasers in surgery and medicine | doi = 10.1002/lsm.10001 }}
2. ^Photodynamic Therapy Using HPPH in Treating Patients With Obstructive Esophageal Tumors
3. ^Photodynamic Therapy Using HPPH in Treating Patients With Advanced Non-Small Cell Lung Cancer That Blocks the Air Passages

External links

Clinical trials of HPPH

{{DEFAULTSORT:Hexyloxyethyl)-2-devinyl pyropheophorbide-a, 2-(1-}}{{pharma-stub}}

1 : Tetrapyrroles

随便看

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。