| 词条 | 2,3-Dichlorophenylpiperazine |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 477210276 | ImageFile = Dichlorophenylpiperazine-ifa.png | ImageSize = | IUPACName = 1-(2,3-dichlorophenyl)piperazine | OtherNames = |Section1={{Chembox Identifiers | InChI1 = 1/C10H12Cl2N2/c11-8-2-1-3-9(10(8)12)14-6-4-13-5-7-14/h1-3,13H,4-7H2 | InChIKey = UDQMXYJSNNCRAS-UHFFFAOYAH | InChIKey1 = UDQMXYJSNNCRAS-UHFFFAOYAH | CASNo_Ref = {{cascite|changed|??}} | CASNo = 41202-77-1 | PubChem = 851833 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C10H12Cl2N2/c11-8-2-1-3-9(10(8)12)14-6-4-13-5-7-14/h1-3,13H,4-7H2 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = UDQMXYJSNNCRAS-UHFFFAOYSA-N | ChemSpiderID = 744460 | SMILES = Clc1c(Cl)c(ccc1)N2CCNCC2 | InChI =1S/C10H12Cl2N2/c11-8-2-1-3-9(10(8)12)14-6-4-13-5-7-14/h1-3,13H,4-7H2 |Section2={{Chembox Properties | Formula = C10H12Cl2N2 | MolarMass = 231.12 g/mol | Appearance = brown oil | Density = 1.272g/cm3 °C | MeltingPtC = 242 to 244 | MeltingPt_notes = | BoilingPtC = 365.1 | BoilingPt_notes = at 760mmHg | Solubility = |Section3={{Chembox Hazards | MainHazards = | FlashPtC = 174.6 | AutoignitionPtC = }} 2,3-Dichlorophenylpiperazine (2,3-DCPP or DCPP) is a chemical compound. It is both a precursor in the synthesis of aripiprazole and one of its metabolites.[1][2] It is unclear whether 2,3-DCPP is pharmacologically active similar to its close analogue 3-chlorophenylpiperazine (mCPP).{{citation needed|date=January 2017}} Legality2,3-DCPP has been made illegal in Japan and Hungary after having been identified in seized designer drug samples.[3][4] DerivativesAs with the related compound mCPP, 2,3-DCPP is an essential precursor to several pharmaceutical drugs which are widely used in medicine, and is also formed as a metabolite of these drugs in patients, although generally only in insignificant amounts.
See also
References1. ^{{cite journal |vauthors=Leś A, Badowska-Rosłonek K, Łaszcz M, Kamieńska-Duda A, Baran P, Kaczmarek Ł | title = Optimization of aripiprazole synthesis | journal = Acta Poloniae Pharmaceutica | volume = 67 | issue = 2 | pages = 151–7 | year = 2010 | pmid = 20369792 | doi = | url = }} {{Piperazines}}{{DEFAULTSORT:Dichlorophenylpiperazine, 2,3-}}2. ^{{cite journal | author = Caccia S | title = N-dealkylation of arylpiperazine derivatives: disposition and metabolism of the 1-aryl-piperazines formed | journal = Current Drug Metabolism | volume = 8 | issue = 6 | pages = 612–22 |date=August 2007 | pmid = 17691920 | doi = 10.2174/138920007781368908| url = http://www.bentham-direct.org/pages/content.php?CDM/2007/00000008/00000006/0005F.SGM}} 3. ^{{cite web | url=http://www.mhlw.go.jp/seisakunitsuite/bunya/kenkou_iryou/iyakuhin/yakubuturanyou/dl/meisho.pdf | title=指定薬物名称・構造式一覧（平成27年9月16日現在） | publisher=厚生労働省 | date=16 September 2015 | language=Japanese | accessdate=6 January 2015}} 4. ^A Magyarországon megjelent, a Kábítószer és Kábítószer-függőség Európai Megfigyelő Központjának Korai Jelzőrendszerébe (EMCDDA EWS) 2005 óta bejelentett ellenőrzött anyagok büntetőjogi vonatkozású besorolása 2 : Chloroarenes|Piperazines |
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