| 词条 | 2,4,6-Trinitrobenzenesulfonic acid |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 477198445 | Name = 2,4,6-Trinitrobenzene Sulfonic Acid | ImageFile = trinitrobenzenesulfonic acid.png | ImageSize = 160px | ImageFile1 = 2,4,6-Trinitrobenzenesulfonic-acid-3D-balls.png | ImageSize1 = 160 | ImageAlt1 = 2,4,6-Trinitrobenzenesulfonic acid molecule | ImageName = | IUPACName = 2,4,6-Trinitrobenzenesulfonic acid | OtherNames = Picrylsulfonic acid; Trinitrobenzene sulfonate; TNBS |Section1={{Chembox Identifiers | 3DMet = | Abbreviations = | Beilstein = | InChI = 1/C6H3N3O9S/c10-7(11)3-1-4(8(12)13)6(19(16,17)18)5(2-3)9(14)15/h1-2H,(H,16,17,18) | InChIKey = NHJVRSWLHSJWIN-UHFFFAOYAG | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C6H3N3O9S/c10-7(11)3-1-4(8(12)13)6(19(16,17)18)5(2-3)9(14)15/h1-2H,(H,16,17,18) | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = NHJVRSWLHSJWIN-UHFFFAOYSA-N | CASNo = 2508-19-2 | CASNo_Ref = {{cascite|changed|??}} | CASNoOther = | ChEBI_Ref = {{ebicite|correct|EBI}} | ChEBI = 53063 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 10577 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | EC_number = | EINECS = | Gmelin = | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = | MeSHName = | PubChem = | RTECS = | SMILES = O=S(=O)(O)c1c(cc(cc1[N+]([O-])=O)[N+]([O-])=O)[N+]([O-])=O | UNNumber =0386 |Section2={{Chembox Properties | AtmosphericOHRateConstant = | Appearance = | BoilingPt = | BoilingPt_notes = | Density = 0.955 g/cm3 | C=6 | H=3 | N=3 | O=9 | S=1 | HenryConstant = | LogP = | MolarMass = | MeltingPt = | MeltingPt_notes = | pKa = | pKb = | Solubility = | SolubleOther = | Solvent = | VaporPressure = |Section3={{Chembox Structure | Coordination = | CrystalStruct = | MolShape = |Section5={{Chembox Thermochemistry | DeltaHc = | DeltaHf = | Entropy = | HeatCapacity = |Section6={{Chembox Pharmacology | ATCvet = | ATCCode_prefix = | ATCCode_suffix = | ATC_Supplemental = | AdminRoutes = | Bioavail = | Excretion = | HalfLife = | Metabolism = | Legal_status = | Legal_US = | Legal_UK = | Legal_AU = | Legal_CA = | Pregnancy_category = | Pregnancy_AU = | Pregnancy_US = | ProteinBound = |Section4={{Chembox Explosive | DetonationV = | FrictionSens = | REFactor = | ShockSens = |Section7={{Chembox Hazards | AutoignitionPt = | EUClass = | ExploLimits = | ExternalSDS = | FlashPt = | LD50 = | MainHazards = | NFPA-H =2 | NFPA-F =4 | NFPA-R =4 | NFPA-S =OX | PEL = | RPhrases = {{R11}} {{R36/38}} | RSPhrases = | SPhrases = {{S16}} {{S26}} {{S33}} {{S37/39}} }} |Section8={{Chembox Related | OtherAnions = | OtherCations = | OtherCompounds = | OtherFunction_label = | OtherFunction = }}Trinitrobenzenesulfonic acid (C6H3N3O9S) is a nitroaryl oxidizing acid. Due to its extreme oxidative properties, if mixed with reducing agents including hydrides, sulfides, and nitrides, it may begin a vigorous reaction that culminates in almost immediate detonation. The aromatic nitro compounds may explode in the presence of a base such as sodium hydroxide or potassium hydroxide even in the presence of water or organic solvents because of the explosive tendencies of aromatic nitro compounds which increase in the presence of multiple nitro groups. Not much is known about this compound, but it is used as a peptide terminal amino group neutralizer and is currently being investigated for its effects on the immune system.[1] UsesIts primary usage is primarily to neutralize peptide terminal amino groups in scientific research.[2] Occasionally it is used as a detonator for certain other explosive compounds. It is also used to induce Crohn's disease in the colon of laboratory animals in order to model inflammatory bowel disease. Health concerns and safety precautionsThe primary hazard of working with 2,4,6-trinitrobenzenesulfonic acid is the risk of instantaneous explosion. 2,4,6-Trinitrobenzenesulfonic acid is an extremely sensitive compound especially when mixed with other compounds, exposed to heat, or exposed to rapid temperature or pressure changes. The toxicological properties of this compound has not been investigated, so all health effects are unknown. To best prevent bodily harm or injury its recommended that all direct contact be avoided and the compound be kept under extremely strict environmentally controlled conditions. In case of spillage its recommended that a local fire department be called in advance prior to any attempt at cleaning. In case of fire its recommended that the material is left to burn and the surrounding area is evacuated. If fire fighting is required its recommended that a fully positive pressure self-contained breathing apparatus is used along with either foam or CO2 extinguishers.[3][4] References1. ^{{cite journal | journal = The Journal of Experimental Medicine | volume = 192 | issue = 1 | year = 2000 | pages = 41–52 | title = Treatment of Experimental (Trinitrobenzene Sulfonic Acid) Colitis by Intranasal Administration of Transforming Growth Factor (Tgf)-β1 Plasmid: TGF-β1–Mediated Suppression of T Helper Cell Type 1 Response Occurs by Interleukin (Il)-10 Induction and IL-12 Receptor β2 Chain Downregulation|author1=Atsushi Kitani |author2=Ivan J. Fuss |author3=Kazuhiko Nakamura |author4=Owen M. Schwartz |author5=Takashi Usui |author6=Warren Strober | url = | doi = 10.1084/jem.192.1.41 | pmid = 10880525 | pmc = 1887715}} {{DEFAULTSORT:Trinitrobenzenesulfonic acid, 2,4,6-}}2. ^Trinitrobenzenesulfonic Acid, Comparative Toxicogenomics Database. 3. ^MSDS, chemcas.com. 4. ^savety, cameochemicals. 3 : Explosive chemicals|Nitrobenzenes|Benzenesulfonic acids |
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