| 词条 | 2,6-Dimethoxybenzoquinone |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 456498687 | Name = 2,6-Dimethoxybenzoquinone | ImageFile = 2,6-Dimethoxy-1,4-benzoquinone.svg | ImageName = Chemical structure of 2,6-dimethoxybenzoquinone | ImageAlt = Chemical structure of 2,6-dimethoxybenzoquinone | IUPACName = 2,6-Dimethoxycyclohexa-2,5-diene-1,4-dione | OtherNames = 2,6-Dimethoxy-1,4-benzoquinone; 2,6-DMBQ |Section1={{Chembox Identifiers | CASNo = 530-55-2 | CASNo_Ref = {{cascite|changed|??}}= | CASNoOther = | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 448515 | PubChem = 68262 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 61560 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = OLBNOBQOQZRLMP-UHFFFAOYSA-N | SMILES = O=C1C(/OC)=C\\C(=O)\\C=C1\\OC | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI=1S/C8H8O4/c1-11-6-3-5(9)4-7(12-2)8(6)10/h3-4H,1-2H3 | MeSHName = }} |Section2={{Chembox Properties | C=8 | H=8 | O=4 | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = }} }}2,6-Dimethoxybenzoquinone (2,6-DMBQ) is a benzoquinone, a chemical compound found in Rauvolfia vomitoria[1] and in Tibouchina pulchra.[2] ToxicityAt physiological concentrations 2,6-Dimethoxy-p-benzoquinone is an antibacterial substance,[3] in non-physiological, highly elevated concentrations might be mutagenic,[4][5] cytotoxic,[5] genotoxic,[6] and hepatotoxic.,[7][8][9] but some scientists challenge its mutagenity [10] and others totally exclude such a possibility[11] References1. ^A note on the occurrence of 2,6-dimethoxybenzoquinone in Rauwolfia vomitoria. S. Morris Kupchan and Mang E. Obasi, Journal of the American Pharmaceutical Association, Volume 49, Issue 4, pages 257–258, April 1960, {{doi|10.1002/jps.3030490421}} {{DEFAULTSORT:Dimethoxybenzoquinone, 2,6-}}2. ^Plant anticancer agents. XI. 2,6-dimethoxybenzoquinone as a cytotoxic constituent of Tibouchina pulchra. Jones E., Ekundayo O. and Kingston D.G.I., Journal of Natural Products, Jul-Aug 1981, {{doi|10.1021/np50016a019}} 3. ^2,6-Dimethoxy-p-benzoquinoneas an antibacterial substance in the bark of Phyllostachys heterocycla var. pubescens, a species of thick-stemmed bamboo Atsuyoshi Nishina, Kinichi Hasegawa, Tsuyoshi Uchibori, Hajime Seino, Toshihiko Osawa J. Agric. Food Chem., 1991, 39 (2), pp 266–269 DOI: 10.1021/jf00002a009 Publication Date: February 1991 4. ^Canonero R; Poggi C Mutagenic activity of 2,6-dimethoxy-1,4-benzoquinone, produced during the nitrosation of dimethophrine, in V 79 cells. Bollettino della Societa italiana di biologia sperimentale (1988), 64(1), 61-8 5. ^1 Brambilla G; Robbiano L; Cajelli E; Martelli A; Turmolini F; Mazzei M Cytotoxic, DNA-damaging and mutagenic properties of 2,6-dimethoxy-1,4-benzoquinone, formed by dimethophrine-nitrite interaction. The Journal of Pharmacology and Experimental Therapeutics (1988), 244(3), 1011-5 6. ^Mazzei M; Roma G; Balbi A; Sottofattori E; Robbiano L Formation of 2,6-dimethoxy-1,4-benzoquinone, a highly genotoxic compound, from the reaction of sodium nitrite with the sympathomimetic drug dimethophrine in acidic aqueous solution. Il Farmaco; edizione scientifica (1988), 43(6), 523-38 7. ^Moore, Gregory A.; Rossi, Luisa; Nicotera, Pierluigi; Orrenius, Sten; O'Brien, Peter J. Quinone toxicity in hepatocytes: studies on mitochondrial calcium release induced by benzoquinone derivatives. Archives of Biochemistry and Biophysics (1987), 259(2), 283-95. 8. ^Siraki, Arno G.; Chan, Tom S.; O'Brien, Peter J. Application of Quantitative Structure-Toxicity Relationships for the Comparison of the Cytotoxicity of 14 p-Benzoquinone Congeners in Primary Cultured Rat Hepatocytes Versus PC12 Cells. Toxicological Sciences (2004), 81(1), 148-159 9. ^Chan, Katie; Jensen, Neil; O'Brien, Peter J. Structure-activity relationships for thiol reactivity and rat or human hepatocyte toxicity induced by substituted p-benzoquinone compounds. Journal of Applied Toxicology (2008), 28(5), 608-620. 10. ^Non-mutagenicity of some wood-related compounds in the bacterial/microsome plate incorporation and microsuspension assays. Mohtashamipur, E., Norpoth, K. International archives of occupational and environmental health. (1984) [Pubmed] 11. ^International Journal of Toxicology, 26:253–259, Safety Studies Regarding a Standardized Extract of Fermented Wheat Germ James T. Heimbach JHeimbach LLC, Port Royal, Virginia, USA Gyula Sebestyen Department of Public Health, Faculty of Medicine, Semmelweis University, Budapest, Hungary Gabor Semjen Department of Pharmacology and Toxicology, Faculty of Veterinary Science, Szent Istvan University, Budapest, Hungary Elke Kennepohl Write-Tox Consulting, Spruce Grove, Alberta, Canada 2 : 1,4-Benzoquinones|Phenol ethers |
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