“2-hydroxy-3-oxoadipate synthase”的意思、由来-开放百科全书

词条

2-hydroxy-3-oxoadipate synthase

释义

References

{{enzyme
| Name = 2-hydroxy-3-oxoadipate synthase
| EC_number = 2.2.1.5
| CAS_number = 9054-72-2
| IUBMB_EC_number = 2/2/1/5
| GO_code = 0050439
| image =
| width =
| caption =
}}

In enzymology, a 2-hydroxy-3-oxoadipate synthase ({{EC number|2.2.1.5}}) is an enzyme that catalyzes the following chemical reaction:

2-oxoglutarate + glyoxylate 2-hydroxy-3-oxoadipate + CO₂

The two substrates of this enzyme are 2-oxoglutarate and glyoxylate, whereas its two products are 2-hydroxy-3-oxoadipate and CO₂.

This enzyme belongs to the family of transferases, specifically those transferring aldehyde or ketonic groups (transaldolases and transketolases, respectively). Other names in common use include 2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating), alpha-ketoglutaric-glyoxylic carboligase, and oxoglutarate: glyoxylate carboligase. This enzyme participates in glyoxylate and dicarboxylate metabolism. It employs one cofactor, thiamin diphosphate.

References

{{cite journal |vauthors=Schlossberg MA, Bloom RJ, Richert DA, Westerfeld WW | date = 1970 | title = Carboligase activity of alpha-ketoglutarate dehydrogenase | journal = Biochemistry | volume = 9 | pages = 1148–53 | pmid = 5418712 | doi = 10.1021/bi00807a015 | issue = 5 }}
{{cite journal |vauthors=Schlossberg MA, Richert DA, Bloom RJ, Westerfeld WW | date = 1968 | title = Isolation and identification of 5-hydroxy-4-ketovaleric acid as a product of alpha-ketoglutarate: glyoxylate carboligase | journal = Biochemistry | volume = 7 | pages = 333–7 | pmid = 4320439 | doi = 10.1021/bi00841a042 | issue = 1 }}
{{cite journal |vauthors=Stewart PR, Quayle JR | date = 1967 | title = The synergistic decarboxylation of glyoxalate and 2-oxoglutarate by an enzyme system from pig-liver mitochondria | journal = Biochem. J. | volume = 102 | pages = 885–897 }}

3 : EC 2.2.1|Thiamine enzymes|Enzymes of unknown structure

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