“2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase”的意思、由来-开放百科全书

词条

2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase

释义

References

{{enzyme
| Name = 2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase
| EC_number = 3.5.1.66
| CAS_number = 95829-26-8
| IUBMB_EC_number = 3/5/1/66
| GO_code = 0047414
| image =
| width =
| caption =
}}

In enzymology, a 2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase ({{EC number|3.5.1.66}}) is an enzyme that catalyzes the chemical reaction

2-(hydroxymethyl)-3-(acetamidomethylene)succinate + 2 H₂O acetate + 2-(hydroxymethyl)-4-oxobutanoate + NH₃ + CO₂

Thus, the two substrates of this enzyme are 2-(hydroxymethyl)-3-(acetamidomethylene)succinate and H₂O, whereas its 4 products are acetate, 2-(hydroxymethyl)-4-oxobutanoate, NH₃, and CO₂.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is 2-(hydroxymethyl)-3-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating). Other names in common use include compound B hydrolase, alpha-hydroxymethyl-alpha'-(N-acetylaminomethylene)succinic acid, and hydrolase. This enzyme participates in vitamin B₆ metabolism.

References

{{cite journal |vauthors=Huynh MS, Snell EE | date = 1985 | title = Enzymes of vitamin B6 degradation. Purification and properties of two N-acetylamidohydrolases | journal = J. Biol. Chem. | volume = 260 | pages = 2379–83 | pmid = 3972793 | issue = 4 }}

{{Carbon-nitrogen non-peptide hydrolases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{3.5-enzyme-stub}}

2 : EC 3.5.1|Enzymes of unknown structure

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