| 词条 | 2β-Propanoyl-3β-(2-naphthyl)-tropane |
| 释义 |
| IUPAC_name = 1-[(1S,3S,4R,5R)-8-methyl-3-naphthalen-2-yl-8-azabicyclo[3.2.1]octan-4-yl]propan-1-one | image=WF-23.svg | CAS_number= | ATC_prefix= | ATC_suffix= | ChemSpiderID = 8623360 | PubChem= 10447943 | DrugBank= | C=21 | H=25 | N=1 | O=1 | molecular_weight = 307.43 g/mol | bioavailability=high | metabolism =slow | elimination_half-life= | excretion = | pregnancy_category = | legal_status = | routes_of_administration= | smiles = CCC(=O)[C@H]1[C@H]2CC[C@@H](C[C@@H]1c3ccc4ccccc4c3)N2C | StdInChI = 1S/C21H25NO/c1-3-20(23)21-18(13-17-10-11-19(21)22(17)2)16-9-8-14-6-4-5-7-15(14)12-16/h4-9,12,17-19,21H,3,10-11,13H2,1-2H3/t17-,18+,19+,21+/m0/s1 | StdInChIKey = WJVLEIDMFWNIAA-QEUVDIPISA-N }}2β-Propanoyl-3β-(2-naphthyl)-tropane or WF-23 is a cocaine analogue. It is claimed to be several hundred times more potent than cocaine at being a serotonin-norepinephrine-dopamine reuptake inhibitor.[1] As can be seen on pubmed, these acyl substituted phenyltropanes are highly potent MAT inhibitors and also have a very long half-life, spanning perhaps at least a few days.[2] [3]See also
External links
References1. ^{{US patent|6008227}} {{Stimulants}}{{Monoamine reuptake inhibitors}}{{Phenyltropanes}}{{DEFAULTSORT:Propanoyl 3 beta 2 Naphthyl Tropane}}2. ^{{cite journal|first1=B. A.|last1=Bennett|first2=C. H.|last2=Wichems|first3=C. K.|last3=Hollingsworth|first4=H. M.|last4=Davies|title=Novel 2-substituted cocaine analogs: uptake and ligand binding studies at dopamine, serotonin and norepinephrine transport sites in the rat brain.|url=http://jpet.aspetjournals.org/content/272/3/1176|journal=Journal of Pharmacology and Experimental Therapeutics|date=1 March 1995|pages=1176–1186|volume=272|issue=3|first5=C.|last5=Thornley|first6=T.|last6=Sexton|first7=S. R.|last7=Childers|pmid=7891330}} 3. ^{{cite journal|first1=J. B.|last1=Daunais|first2=S. L.|last2=Hart|first3=H. R.|last3=Smith|first4=S. R.|last4=Letchworth|title=Long-Acting Blockade of Biogenic Amine Transporters in Rat Brain by Administration of the Potent Novel Tropane 2β-Propanoyl-3β-(2-Naphthyl)-Tropane|url=http://jpet.aspetjournals.org/content/285/3/1246.full|journal=Journal of Pharmacology and Experimental Therapeutics|date=1 June 1998|pages=1246–1254|volume=285|issue=3|first5=H. M. L.|last5=Davies|first6=T.|last6=Sexton|first7=B. A.|last7=Bennett|first8=S. R.|last8=Childers|first9=L. J.|last9=Porrino|pmid=9618429}} 5 : Tropanes|Serotonin-norepinephrine-dopamine reuptake inhibitors|Stimulants|Naphthalenes|Ketones |
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