“3-Aminopyridine”的意思、由来-开放百科全书

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3-Aminopyridine

释义

Preparation
Toxicity
References

{{Chembox
| Watchedfields = changed
| verifiedrevid = 477218162
| ImageFile = 3-aminopyridine.svg
| ImageSize = 120px
| IUPACName = Pyridin-3-amine
| OtherNames = 3-Pyridinamine; 3-Pyridylamine
| Section1 = {{Chembox Identifiers
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 9615
| CASNo_Ref = {{cascite|correct|CAS}}
| CASNo = 462-08-8
| PubChem = 10009
| SMILES = C1=CC(=CN=C1)N
}}
| Section2 = {{Chembox Properties
| C=5|H=6|N=2
| Appearance = {{citation needed|reason=Dull brown crystals|date=May 2017}}
| Density =
| MeltingPtC = 65
| BoilingPtC = 248
| Solubility = Soluble{{vague|date=November 2013}}
| SolubleOther = Soluble{{vague|date=November 2013}}
| Solvent = alcohol and benzene}}
| Section3 = {{Chembox Hazards
| MainHazards =
| FlashPtC = 124
| AutoignitionPtC = 628
}}
}}3-Aminopyridine is an aminopyridine. It is a colorless solid.^[1]

Preparation

3-Aminopyridine is prepared by heating nicotinamide with sodium hypobromite which is in turn prepared in situ by the reaction of sodium hydroxide and bromine at 70 °C.^[1]

It can be used in the synthesis of organic ligand 3-pyridylnicotinamide.

Toxicity

The acute toxicity is indicated by the LD50 = 178 mg/kg (quail, oral).^[2]

References

1. ^{{OrgSynth|first1 = C. F. H.|last1 = Allen|first2 = Calvin N.|last2 = Wolf|year = 1950|title = 3-Aminopyridine|volume = 30|pages = 3|collvol = 4|collvolpages = 45|prep = CV4P0045|doi = 10.15227/orgsyn.030.0003}}
2. ^¹{{Ullmann|authors=Shinkichi Shimizu, Nanao Watanabe, Toshiaki Kataoka, Takayuki Shoji, Nobuyuki Abe, Sinji Morishita, Hisao Ichimura|title=Pyridine and Pyridine Derivatives|year=2000|doi=10.1002/14356007.a22_399}}

1 : Pyridines

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