“3-hydroxyisobutyryl-CoA hydrolase”的意思、由来-开放百科全书

词条

3-hydroxyisobutyryl-CoA hydrolase

释义

References

{{enzyme
| Name = 3-hydroxyisobutyryl-CoA hydrolase
| EC_number = 3.1.2.4
| CAS_number = 9025-88-1
| IUBMB_EC_number = 3/1/2/4
| GO_code = 0003860
| image =
| width =
| caption =
}}

In enzymology, a 3-hydroxyisobutyryl-CoA hydrolase ({{EC number|3.1.2.4}}) is an enzyme that catalyzes the chemical reaction

3-hydroxy-2-methylpropanoyl-CoA + H₂O CoA + 3-hydroxy-2-methylpropanoate

Thus, the two substrates of this enzyme are 3-hydroxy-2-methylpropanoyl-CoA and H₂O, whereas its two products are CoA and 3-hydroxy-2-methylpropanoate.

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is 3-hydroxy-2-methylpropanoyl-CoA hydrolase. Other names in common use include 3-hydroxy-isobutyryl CoA hydrolase, and HIB CoA deacylase. This enzyme participates in 3 metabolic pathways: valine, leucine and isoleucine degradation, beta-alanine metabolism, and propanoate metabolism. 3-hydroxyisobutyryl-CoA hydrolase is encoded by HIBCH gene.^[1]

References

1. ^{{Cite web|url=https://www.omim.org/entry/610690?|title=OMIM Entry - * 610690 - 3-HYDROXYISOBUTYRYL-CoA HYDROLASE; HIBCH|website=www.omim.org|language=en-us|access-date=2017-11-20}}

{{cite journal | vauthors = Rendina G, Coon MJ | title = Enzymatic hydrolysis of the coenzyme a thiol esters of beta-hydroxypropionic and beta-hydroxyisobutyric acids | journal = The Journal of Biological Chemistry | volume = 225 | issue = 1 | pages = 523–34 | date = March 1957 | pmid = 13457352 }}

2 : EC 3.1.2|Enzymes of unknown structure

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