“3-Hydroxypentanoic acid”的意思、由来-开放百科全书

词条

3-Hydroxypentanoic acid

释义

References

{{chembox
| Verifiedfields = changed
| verifiedrevid = 477218913
| ImageFile=3-hydroxypentanoic acid.png
| ImageSize=200px
| IUPACName=3-Hydroxypentanoic acid
| OtherNames=3-Hydroxyvalerate
3-Hydroxy valeric acid
beta-Hydroxyvaleric acid
beta-Hydroxypentanoate
|Section1={{Chembox Identifiers
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 96952
| InChI = 1/C5H10O3/c1-2-4(6)3-5(7)8/h4,6H,2-3H2,1H3,(H,7,8)
| InChIKey = REKYPYSUBKSCAT-UHFFFAOYAT
| SMILES1 = O=C(O)CC(O)CC
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C5H10O3/c1-2-4(6)3-5(7)8/h4,6H,2-3H2,1H3,(H,7,8)
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = REKYPYSUBKSCAT-UHFFFAOYSA-N
| CASNo_Ref = {{cascite|changed|??}}
| CASNo=10237-77-1
| PubChem=107802
| SMILES=CCC(CC(=O)O)O
|Section2={{Chembox Properties
| Formula=C₅H₁₀O₃
| MolarMass=118.13 g/mol
| Appearance=
| Density=
| MeltingPt=
| BoilingPt=
| Solubility=
|Section3={{Chembox Hazards
| MainHazards=
| FlashPt=
| AutoignitionPt =
}}3-Hydroxypentanoic acid, or beta-hydroxypentanoate is a 5-carbon ketone body. It is made from odd carbon fatty acids in the liver and rapidly enters the brain. As opposed to 4-carbon ketone bodies, 3-hydroxypentanoic acid is anaplerotic, meaning it can refill the pool of TCA cycle intermediates. The triglyceride triheptanoin is used clinically to produce beta-hydroxypentanoate.^[1]

References

1. ^{{cite journal| title=Parenteral and Enteral Metabolism of Anaplerotic Triheptanoin in Normal Rats| author=Renée P. Kinman| author2=Takhar Kasumov| author3=Kathryn A. Jobbins| author4=Katherine R. Thomas| author5=Jillian Adams| author6=Lisa N. Brunengraber| author7=Gerd Kutz| author8=Wolf-Ulrich Brewer| author9=Charles R. Roe| author10=Henri Brunengraber| last-author-amp=yes| journal=Am J Physiol Endocrinol Metab| pages=E860–E866| volume=291| doi=10.1152/ajpendo.00366.2005| year=2006| pmid=16705058| issue=4}} Reprint

1 : Beta hydroxy acids

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