“3-Oxopentanoic acid”的意思、由来-开放百科全书

词条

3-Oxopentanoic acid

释义

References

{{chembox
| Verifiedfields = changed
| verifiedrevid = 477220034
| ImageFile=3-oxopentanoic acid.png
| ImageSize=200px
| IUPACName=3-Oxopentanoic acid
| OtherNames=beta-Ketopentanoate
3-Oxopentanoate
3-Oxovaleric acid
3-Ketovaleric acid
|Section1={{Chembox Identifiers
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 388751
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = C02233
| InChI = 1/C5H8O3/c1-2-4(6)3-5(7)8/h2-3H2,1H3,(H,7,8)
| SMILES1 = O=C(CC)CC(=O)O
| InChIKey = FHSUFDYFOHSYHI-UHFFFAOYAQ
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C5H8O3/c1-2-4(6)3-5(7)8/h2-3H2,1H3,(H,7,8)
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = FHSUFDYFOHSYHI-UHFFFAOYSA-N
| CASNo_Ref = {{cascite|changed|??}}
| CASNo=10191-25-0
| PubChem=439684
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 27401
| SMILES=CCC(=O)CC(=O)O
|Section2={{Chembox Properties
| Formula=C₅H₈O₃
| MolarMass=116.12 g/mol
| Appearance=
| Density=
| MeltingPt=
| BoilingPt=
| Solubility=
|Section3={{Chembox Hazards
| MainHazards=
| FlashPt=
| AutoignitionPt =
}}

3-Oxopentanoic acid, or beta-ketopentanoate, is a 5-carbon ketone body. It is made from odd carbon fatty acids in the liver and rapidly enters the brain.

As opposed to 4-carbon ketone bodies, beta-ketopentanoate is anaplerotic, meaning it can refill the pool of TCA cycle intermediates. The triglyceride triheptanoin is used clinically to produce beta-ketopentanoate.^[1]

References

1. ^{{cite journal| title=Parenteral and Enteral Metabolism of Anaplerotic Triheptanoin in Normal Rats| author=Renée P. Kinman| author2=Takhar Kasumov| author3=Kathryn A. Jobbins| author4=Katherine R. Thomas| author5=Jillian Adams| author6=Lisa N. Brunengraber| author7=Gerd Kutz| author8=Wolf-Ulrich Brewer| author9=Charles R. Roe| author10=Henri Brunengraber| last-author-amp=yes| journal=Am J Physiol Endocrinol Metab| pages=E860–E866| volume=291| doi=10.1152/ajpendo.00366.2005| year=2006| pmid=16705058| issue=4}} Reprint

2 : Ketones|Carboxylic acids

随便看

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。