| 词条 | 4-Fluoro-5-methoxy-DMT |
| 释义 |
| verifiedrevid = 451563257 | IUPAC_name = 4-Fluoro-5-Methoxy-N,N-dimethyltryptamine | image = 4-Fluoro-5-methoxy-N,N-dimethyltryptamine.svg | width = | tradename = | pregnancy_category = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 312314-18-4 | ATC_prefix = | ATC_suffix = | PubChem = 10082834 | ChemSpiderID = 8258372 | C=13 | H=17 | F=1 | N=2 | O=1 | molecular_weight = 236.13 g/mol | smiles = CN(C)CCC1=CNC2=C1C(=C(C=C2)OC)F | StdInChI = 1S/C13H17FN2O/c1-16(2)7-6-9-8-15-10-4-5-11(17-3)13(14)12(9)10/h4-5,8,15H,6-7H2,1-3H3 | StdInChIKey = CTEKFOKTEGQYLO-UHFFFAOYSA-N }}4-Fluoro-5-Methoxy-N,N-dimethyltryptamine (4-F-5-MeO-DMT) was first described by David E. Nichols team in 2000. It is a potent 5-HT1A agonist. Substitution with the 4-fluorine markedly increased 5-HT1A selectivity over 5-HT2A/2C receptors with potency greater than that of the 5-HT1A agonist 8-OH-DPAT.[1] The analog compound with the N,N-dialkyl substituents constrained into a pyrrolidine ring, is a slightly stronger agonist for the 5-HT1A receptor and retains the selectivity over the 5-HT2A/2C receptors.[2] See also
References1. ^{{cite journal | author = Joseph B. Blair | author2 = Deborah Kurrasch-Orbaugh | author3 = Danuta Marona-Lewicka| author4 = Medhane G. Cumbay | author5 = Val J. Watts| author6 = Eric L. Barker | author7 = David E. Nichols | last-author-amp = yes | title = Effect of Ring Fluorination on the Pharmacology of Hallucinogenic Tryptamines | journal = Journal of Medicinal Chemistry | year = 2000 | volume = 43 | issue = 24 | pmid = 11101361 | pages = 4701–4710 | doi = 10.1021/jm000339w }} {{Hallucinogens}}{{Serotonergics}}{{Tryptamines}}{{DEFAULTSORT:Fluoro-5-methoxy-DMT, 4-}}{{hallucinogen-stub}}2. ^{{cite journal | doi = 10.1016/S0960-894X(01)00062-2 | author = Uros Laban | author2 = Deborah Kurrasch-Orbaugh | author3 = Danuta Marona-Lewicka | author4 = David E. Nichols | last-author-amp = yes | title = A Novel Fluorinated Tryptamine with Highly Potent Serotonin 5-HT1A Receptor Agonist Properties | journal = Bioorganic & Medicinal Chemistry Letters | year = 2001 | volume = 11 | issue = 6 | pages = 793–795 | pmid = 11277522 }} 2 : Psychedelic tryptamines|Serotonin receptor agonists |
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