| 词条 | 4-Iodopropofol |
| 释义 |
| Verifiedfields = changed | verifiedrevid = 477222419 | IUPAC_name = 2,6-diisopropyl-4-iodophenol | image = 4-iodopropofol.png | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | dependency_liability = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 169255-48-5 | ATC_prefix = | ATC_suffix = | ATC_supplemental = | PubChem = 9882905 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 8058580 | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 53267 | chemical_formula = | C=12 | H=17 | I=1 | O=1 | molecular_weight = 304.167 g/mol | smiles = Oc1c(C(C)C)cc(I)cc1C(C)C | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C12H17IO/c1-7(2)10-5-9(13)6-11(8(3)4)12(10)14/h5-8,14H,1-4H3 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = JMJHJCFWTNRPEI-UHFFFAOYSA-N }}4-Iodopropofol is a drug derived from the commonly used sedative anaesthetic agent, propofol. 4-Iodopropofol has similar effects to propofol on isolated receptors, acting primarily as a GABAA positive modulator and sodium channel blocker,[1][2][3][4] but when given to animals it has only anxiolytic and anticonvulsant effects, lacking the strong sedative-hypnotic profile of propofol.[5] References1. ^{{cite journal | last1 = Trapani | first1 = G | last2 = Latrofa | first2 = A | last3 = Franco | first3 = M | last4 = Altomare | first4 = C | last5 = Sanna | first5 = E | last6 = Usala | first6 = M | last7 = Biggio | first7 = G | last8 = Liso | first8 = G | title = Propofol analogues. Synthesis, relationships between structure and affinity at GABAA receptor in rat brain, and differential electrophysiological profile at recombinant human GABAA receptors | journal = Journal of Medicinal Chemistry | volume = 41 | issue = 11 | pages = 1846–54 | year = 1998 | pmid = 9599235 | doi = 10.1021/jm970681h }} {{Anxiolytics}}{{DEFAULTSORT:Iodopropofol, 4-}}2. ^{{cite journal | last1 = Lingamaneni | first1 = R | last2 = Krasowski | first2 = MD | last3 = Jenkins | first3 = A | last4 = Truong | first4 = T | last5 = Giunta | first5 = AL | last6 = Blackbeer | first6 = J | last7 = MacIver | first7 = MB | last8 = Harrison | first8 = NL | last9 = Hemmings Jr | first9 = HC | title = Anesthetic properties of 4-iodopropofol: implications for mechanisms of anesthesia | journal = Anesthesiology | volume = 94 | issue = 6 | pages = 1050–7 | year = 2001 | pmid = 11465597 | doi = 10.1097/00000542-200106000-00020 }} 3. ^{{cite journal | last1 = Krasowski | first1 = MD | last2 = Hong | first2 = X | last3 = Hopfinger | first3 = AJ | last4 = Harrison | first4 = NL | title = 4D-QSAR Analysis of a Set of Propofol Analogues: Mapping Binding Sites for an Anesthetic Phenol on the GABAA Receptor | journal = Journal of Medicinal Chemistry | volume = 45 | issue = 15 | pages = 3210–21 | year = 2002 | pmid = 12109905 | pmc = 2864546 | doi=10.1021/jm010461a}} 4. ^{{cite journal | last1 = Haeseler | first1 = G | last2 = Karst | first2 = M | last3 = Foadi | first3 = N | last4 = Gudehus | first4 = S | last5 = Roeder | first5 = A | last6 = Hecker | first6 = H | last7 = Dengler | first7 = R | last8 = Leuwer | first8 = M | title = High-affinity blockade of voltage-operated skeletal muscle and neuronal sodium channels by halogenated propofol analogues | journal = British Journal of Pharmacology | volume = 155 | issue = 2 | pages = 265–75 | year = 2008 | pmid = 18574460 | pmc = 2538694 | doi = 10.1038/bjp.2008.255 }} 5. ^{{cite journal | last1 = Sanna | first1 = E | last2 = Motzo | first2 = C | last3 = Usala | first3 = M | last4 = Serra | first4 = M | last5 = Dazzi | first5 = L | last6 = MacIocco | first6 = E | last7 = Trapani | first7 = G | last8 = Latrofa | first8 = A | last9 = Liso | first9 = G | last10 = Biggio | first10 = G | title = Characterization of the electrophysiological and pharmacological effects of 4-iodo-2,6-diisopropylphenol, a propofol analogue devoid of sedative-anaesthetic properties | journal = British Journal of Pharmacology | volume = 126 | issue = 6 | pages = 1444–54 | year = 1999 | pmid = 10217539 | pmc = 1565920 | doi = 10.1038/sj.bjp.0702449 }} 4 : Anticonvulsants|Anxiolytics|Phenols|Iodoarenes |
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