| 词条 | 4'-Methyl-α-pyrrolidinopropiophenone |
| 释义 |
| IUPAC_name = (RS)-1-(4-methylphenyl)-2-(1-pyrrolidinyl)-1-propanone | image = PMPPP.svg | width = 200px | CAS_number = 1313393-58-6 | CAS_supplemental = 28117-80-8 | ATC_prefix = | ATC_suffix = | PubChem = 6430745 | DrugBank = | C=14|H=19|N=1|O=1 | molecular_weight = 217.3081 g/mol | smiles = CC1=CC=C(C=C1)C(=O)C(C)N2CCCC2 | ChemSpiderID = 4936084 | StdInChI = 1S/C14H19NO/c1-11-5-7-13(8-6-11)14(16)12(2)15-9-3-4-10-15/h5-8,12H,3-4,9-10H2,1-2H3 | StdInChIKey = APSJUNFBAXIXLK-UHFFFAOYSA-N | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | pregnancy_AU = | pregnancy_US = | pregnancy_category= | legal_AU = | legal_CA = | legal_UK = Class B | legal_US = Schedule I | legal_DE = Anlage I | legal_status = Banned in Sweden [1] | routes_of_administration = | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 0TY023967I }}4'-Methyl-α-pyrrolidinopropiophenone (4-MePPP, MPPP or MαPPP) is a stimulant drug and substituted cathinone. It is structurally very similar to α-PPP, with only one added methyl group in the para position on the phenyl ring. 4-MePPP was sold in Germany as a designer drug in the late 1990s and early 2000s,[2][3][4] along with a number of other pyrrolidinophenone derivatives.[5][6] Although it has never achieved the same international popularity as its better-known relations α-PPP and MDPV, 4-MePPP is still sometimes found as an ingredient of grey-market "bath salt" blends[7] such as "NRG-3".[7] See also
References1. ^{{cite web | url=http://www.folkhalsomyndigheten.se/nyheter-och-press/nyhetsarkiv/2014/november/cannabinoider-foreslas-bli-klassade-som-halsofarlig-vara/ | title=Cannabinoider föreslås bli klassade som hälsofarlig vara | accessdate=29 June 2015}} {{Stimulants}}{{Adrenergics}}{{Dopaminergics}}{{DEFAULTSORT:Methyl-A-Pyrrolidinopropiophenone, 4'-}}{{nervous-system-drug-stub}}2. ^{{cite journal | last1 = Springer | first1 = D | last2 = Peters | first2 = FT | last3 = Fritschi | first3 = G | last4 = Maurer | first4 = HH | title = Studies on the metabolism and toxicological detection of the new designer drug 4'-methyl-alpha-pyrrolidinopropiophenone in urine using gas chromatography-mass spectrometry | journal = Journal of Chromatography B | volume = 773 | issue = 1 | pages = 25–33 | year = 2002 | pmid = 12015267 | doi = 10.1016/S1570-0232(01)00578-5 }} 3. ^{{cite journal | last1 = Springer | first1 = D | last2 = Paul | first2 = LD | last3 = Staack | first3 = RF | last4 = Kraemer | first4 = T | last5 = Maurer | first5 = HH | title = Identification of cytochrome p450 enzymes involved in the metabolism of 4'-methyl-alpha-pyrrolidinopropiophenone, a novel scheduled designer drug, in human liver microsomes | journal = Drug Metabolism and Disposition | volume = 31 | issue = 8 | pages = 979–82 | year = 2003 | pmid = 12867484 | doi = 10.1124/dmd.31.8.979 }} 4. ^{{cite journal | last1 = Springer | first1 = D | last2 = Fritschi | first2 = G | last3 = Maurer | first3 = HH | title = Metabolism of the new designer drug alpha-pyrrolidinopropiophenone (PPP) and the toxicological detection of PPP and 4'-methyl-alpha-pyrrolidinopropiophenone (MPPP) studied in rat urine using gas chromatography-mass spectrometry | journal = Journal of Chromatography B | volume = 796 | issue = 2 | pages = 253–66 | year = 2003 | pmid = 14581066 | doi = 10.1016/j.jchromb.2003.07.008 }} 5. ^{{cite journal | last1 = Maurer | first1 = HH | last2 = Kraemer | first2 = T | last3 = Springer | first3 = D | last4 = Staack | first4 = RF | title = Chemistry, pharmacology, toxicology, and hepatic metabolism of designer drugs of the amphetamine (ecstasy), piperazine, and pyrrolidinophenone types: a synopsis | journal = Therapeutic drug monitoring | volume = 26 | issue = 2 | pages = 127–31 | year = 2004 | pmid = 15228152 | doi = 10.1097/00007691-200404000-00007 }} 6. ^{{cite journal | last1 = Staack | first1 = RF | last2 = Maurer | first2 = HH | title = Metabolism of designer drugs of abuse | journal = Current Drug Metabolism | volume = 6 | issue = 3 | pages = 259–74 | year = 2005 | pmid = 15975043 | doi = 10.2174/1389200054021825 }} 7. ^1 {{cite journal |vauthors=Brandt SD, Freeman S, Sumnall HR, Measham F, Cole J |title=Analysis of NRG 'legal highs' in the UK: identification and formation of novel cathinones |journal=Drug Testing and Analysis |volume= 3|issue= 9|pages= 569–75|date=December 2010 |pmid=21960541 |doi=10.1002/dta.204 |url=}} 3 : Designer drugs|Pyrrolidinophenones|Stimulants |
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