| 词条 | 5'-Guanylyl imidodiphosphate |
| 释义 |
| Verifiedfields = changed | verifiedrevid = 436747408 | ImageFile = 5'-Guanylyl imidodiphosphate.svg | ImageSize = 200px | IUPACName = [[[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]amino]phosphonic acid | OtherNames = GppNHp; GppNP; GMP-Pnp; GDP-NP Guanylyl imidodiphosphate 5-Guanylylimidodiphosphate 5'-Guanylyliminodiphosphonate | Section1 = {{Chembox Identifiers | CASNo_Ref = {{cascite|correct|??}} | CASNo = 34273-04-6 | CASNo1_Ref = {{cascite|changed|??}} | CASNo1 = 148892-91-5 | CASNo1_Comment = (trisodium salt)[1] | PubChem = 36735 | ChEBI_Ref = {{ebicite|changed|EBI}} | ChEBI = 78408 | SMILES = C1=NC2=C(N1[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O)OP(=O)(NP(=O)(O)O)O)O)O)NC(=NC2=O)N | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 33738 | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C10H17N6O13P3/c11-10-13-7-4(8(19)14-10)12-2-16(7)9-6(18)5(17)3(28-9)1-27-32(25,26)29-31(23,24)15-30(20,21)22/h2-3,5-6,9,17-18H,1H2,(H,25,26)(H3,11,13,14,19)(H4,15,20,21,22,23,24)/t3-,5-,6-,9-/m1/s1 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = UQABYHGXWYXDTK-UUOKFMHZSA-N | Section2 = {{Chembox Properties | C=10|H=17|N=6|O=13|P=3 | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = | Section3 = {{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }}5'-Guanylyl imidodiphosphate is a purine nucleotide. It is an analog of guanosine triphosphate in which one of the oxygen atoms is replaced with an amine, producing a non-hydrolyzable functional group. Guanylyl imidodiphosphate binds tightly to G-proteins in the presence of Mg2+.[2] Guanylyl imidodiphosphate is a potent stimulator of adenylate cyclase.[2] It is often used in studies of protein synthesis.[3][4] References1. ^Guanosine 5′-β,γ-imidotriphosphate trisodium salt hydrate at Sigma-Aldrich {{DEFAULTSORT:Guanylyl imidodiphosphate, 5'-}}2. ^1 [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=36735&loc=ec_rcs Guanylyl imidodiphosphate] at PubChem 3. ^{{cite journal | author = Miller, J.D. | author2 = Walter, P. | last-author-amp = yes | title = A GTPase cycle in initiation of protein translocation across the endoplasmic reticulum membrane | journal = Ciba Found. Symp. | volume = 176 | pages = 147–163 | year = 1993 | pmid = 8299417 }} 4. ^{{cite journal | doi = 10.1126/science.252.5009.1171 | author = Connolly, T. | title = Requirement of GTP hydrolysis for dissociation of the signal recognition particle from its receptor | journal = Science | volume = 252 | issue = 5009 | pages = 1171–1173 | year = 1991 | pmid=1851576 |display-authors=etal}} 3 : Nucleotides|Purines|Organophosphates |
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