| 释义 |
- Function
- Interactions
- References
- Further reading
- External links
{{For|the programming language RPL-11|Filetab}}{{Infobox_gene}}60S ribosomal protein L11 is a protein that in humans is encoded by the RPL11 gene.[1][2][3] Function Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L5P family of ribosomal proteins. It is located in the cytoplasm. The protein probably associates with the 5S rRNA. Alternative splice variants encoding different isoforms may exist, but they have not been fully characterized. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[3] Interactions RPL11 has been shown to interact with: - BLMH,[4]
- Mdm2,[6][5]
- P16,[6]
- P53,[6] and
- Promyelocytic leukemia protein[7]
References 1. ^{{cite journal | vauthors = Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC | title = A map of 75 human ribosomal protein genes | journal = Genome Res | volume = 8 | issue = 5 | pages = 509–23 | date = Aug 1998 | pmid = 9582194 | pmc = | doi = 10.1101/gr.8.5.509 }}
2. ^{{cite journal | vauthors = Graphodatsky AS, Vorobieva NV, Filipenko ML, Voronina EV, Frengen E, Prydz H | title = Assignment of the L11 ribosomal protein gene (RPL11) to human chromosome 1p36.1→p35 by in situ hybridization | journal = Cytogenet Cell Genet | volume = 84 | issue = 1–2 | pages = 97–98 | date = Jun 1999 | pmid = 10343117 | pmc = | doi = 10.1159/000015228 }}
3. ^1 {{cite web | title = Entrez Gene: RPL11 ribosomal protein L11| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6135| accessdate = }}
4. ^{{cite journal | vauthors = Koldamova RP, Lefterov IM, DiSabella MT, Almonte C, Watkins SC, Lazo JS | title = Human bleomycin hydrolase binds ribosomal proteins | journal = Biochemistry | volume = 38 | issue = 22 | pages = 7111–7 | date = Jun 1999 | pmid = 10353821 | doi = 10.1021/bi990135l }}
5. ^{{cite journal | vauthors = Dai MS, Sun XX, Lu H | title = Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2 | journal = Mol. Cell. Biol. | volume = 28 | issue = 13 | pages = 4365–76 | date = Jul 2008 | pmid = 18426907 | pmc = 2447154 | doi = 10.1128/MCB.01662-07 }}
6. ^1 2 {{cite journal | vauthors = Zhang Y, Wolf GW, Bhat K, Jin A, Allio T, Burkhart WA, Xiong Y | title = Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway | journal = Mol. Cell. Biol. | volume = 23 | issue = 23 | pages = 8902–12 | date = Dec 2003 | pmid = 14612427 | pmc = 262682 | doi = 10.1128/mcb.23.23.8902-8912.2003}}
7. ^{{cite journal | vauthors = Bernardi R, Scaglioni PP, Bergmann S, Horn HF, Vousden KH, Pandolfi PP | title = PML regulates p53 stability by sequestering Mdm2 to the nucleolus | journal = Nat. Cell Biol. | volume = 6 | issue = 7 | pages = 665–72 | date = Jul 2004 | pmid = 15195100 | doi = 10.1038/ncb1147 }}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Wool IG, Chan YL, Glück A | title = Structure and evolution of mammalian ribosomal proteins | journal = Biochem. Cell Biol. | volume = 73 | issue = 11–12 | pages = 933–947 | year = 1996 | pmid = 8722009 | doi = 10.1139/o95-101 }}
- {{cite journal | vauthors = Mishin VP, Filipenko ML, Muravlev AI, Karpova GG, Mertvetsov NP | title = [Cloning and determination of the primary structure of DNA complementary to the mRNA of human ribosomal protein L11] | journal = Bioorg. Khim. | volume = 21 | issue = 2 | pages = 158–60 | year = 1995 | pmid = 7748210 | doi = }}
- {{cite journal | vauthors = Kato S, Sekine S, Oh SW, Kim NS, Umezawa Y, Abe N, Yokoyama-Kobayashi M, Aoki T | title = Construction of a human full-length cDNA bank | journal = Gene | volume = 150 | issue = 2 | pages = 243–250 | year = 1995 | pmid = 7821789 | doi = 10.1016/0378-1119(94)90433-2 }}
- {{cite journal | vauthors = Koldamova RP, Lefterov IM, DiSabella MT, Almonte C, Watkins SC, Lazo JS | title = Human bleomycin hydrolase binds ribosomal proteins | journal = Biochemistry | volume = 38 | issue = 22 | pages = 7111–7117 | year = 1999 | pmid = 10353821 | doi = 10.1021/bi990135l }}
- {{cite journal | vauthors = Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI | title = Directed proteomic analysis of the human nucleolus | journal = Curr. Biol. | volume = 12 | issue = 1 | pages = 1–11 | year = 2002 | pmid = 11790298 | doi = 10.1016/S0960-9822(01)00650-9 }}
- {{cite journal | vauthors = Voronina EN, Kolokol'tsova TD, Nechaeva EA, Filipenko ML | title = [Structural and functional analysis of the human ribosomal protein L11 gene] | journal = Mol. Biol. (Mosk.) | volume = 37 | issue = 3 | pages = 425–35 | year = 2003 | pmid = 12815950 | doi = }}
- {{cite journal | vauthors = Lohrum MA, Ludwig RL, Kubbutat MH, Hanlon M, Vousden KH | title = Regulation of HDM2 activity by the ribosomal protein L11 | journal = Cancer Cell | volume = 3 | issue = 6 | pages = 577–587 | year = 2004 | pmid = 12842086 | doi = 10.1016/S1535-6108(03)00134-X }}
- {{cite journal | vauthors = Odintsova TI, Müller EC, Ivanov AV, Egorov TA, Bienert R, Vladimirov SN, Kostka S, Otto A, Wittmann-Liebold B, Karpova GG | title = Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing | journal = J. Protein Chem. | volume = 22 | issue = 3 | pages = 249–258 | year = 2004 | pmid = 12962325 | doi = 10.1023/A:1025068419698 }}
- {{cite journal | vauthors = Zhang Y, Wolf GW, Bhat K, Jin A, Allio T, Burkhart WA, Xiong Y | title = Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway | journal = Mol. Cell. Biol. | volume = 23 | issue = 23 | pages = 8902–8912 | year = 2003 | pmid = 14612427 | pmc = 262682 | doi = 10.1128/MCB.23.23.8902-8912.2003 }}
- {{cite journal | vauthors = Bhat KP, Itahana K, Jin A, Zhang Y | title = Essential role of ribosomal protein L11 in mediating growth inhibition-induced p53 activation | journal = EMBO J. | volume = 23 | issue = 12 | pages = 2402–2412 | year = 2004 | pmid = 15152193 | pmc = 423289 | doi = 10.1038/sj.emboj.7600247 }}
- {{cite journal | vauthors = Bernardi R, Scaglioni PP, Bergmann S, Horn HF, Vousden KH, Pandolfi PP | title = PML regulates p53 stability by sequestering Mdm2 to the nucleolus | journal = Nat. Cell Biol. | volume = 6 | issue = 7 | pages = 665–672 | year = 2004 | pmid = 15195100 | doi = 10.1038/ncb1147 }}
- {{cite journal | vauthors = Dai MS, Lu H | title = Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5 | journal = J. Biol. Chem. | volume = 279 | issue = 43 | pages = 44475–44482 | year = 2004 | pmid = 15308643 | doi = 10.1074/jbc.M403722200 }}
- {{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–1178 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
- {{cite journal | vauthors = Dai MS, Shi D, Jin Y, Sun XX, Zhang Y, Grossman SR, Lu H | title = Regulation of the MDM2-p53 pathway by ribosomal protein L11 involves a post-ubiquitination mechanism | journal = J. Biol. Chem. | volume = 281 | issue = 34 | pages = 24304–24313 | year = 2006 | pmid = 16803902 | pmc = 1783840 | doi = 10.1074/jbc.M602596200 }}
- {{cite journal | vauthors = Lindström MS, Jin A, Deisenroth C, White Wolf G, Zhang Y | title = Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradation | journal = Mol. Cell. Biol. | volume = 27 | issue = 3 | pages = 1056–1068 | year = 2007 | pmid = 17116689 | pmc = 1800693 | doi = 10.1128/MCB.01307-06 }}
{{refend}} External links - [https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=diamond-b GeneReviews/NCBI/NIH/UW entry on Diamond-Blackfan Anemia]
{{GeneticTranslation}}{{Ribosome subunits}}{{gene-1-stub}} 1 : Ribosomal proteins |