| 释义 |
- Function
- Interactions
- References
- Further reading
{{Infobox_gene}}60S ribosomal protein L12 is a protein that in humans is encoded by the RPL12 gene.[1][2] Function Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L11P family of ribosomal proteins. It is located in the cytoplasm. The protein binds directly to the 26S rRNA. This gene is co-transcribed with the U65 snoRNA, which is located in its fourth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[2] Interactions RPL12 has been shown to interact with CDC5L.[3] References 1. ^{{cite journal | vauthors = Chu W, Presky DH, Swerlick RA, Burns DK | title = The primary structure of human ribosomal protein L12 | journal = Nucleic Acids Res | volume = 21 | issue = 3 | pages = 749 | date = March 1993 | pmid = 8441690 | pmc = 309184 | doi = 10.1093/nar/21.3.749 }}
2. ^1 {{cite web | title = Entrez Gene: RPL12 ribosomal protein L12| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6136| accessdate = }}
3. ^{{cite journal | vauthors = Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI | title = Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry | journal = EMBO J. | volume = 19 | issue = 23 | pages = 6569–81 | date = December 2000 | pmid = 11101529 | pmc = 305846 | doi = 10.1093/emboj/19.23.6569 }}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Wool IG, Chan YL, Glück A | title = Structure and evolution of mammalian ribosomal proteins | journal = Biochem. Cell Biol. | volume = 73 | issue = 11–12 | pages = 933–47 | year = 1996 | pmid = 8722009 | doi = 10.1139/o95-101 }}
- {{cite journal | vauthors = Kato S, Sekine S, Oh SW, Kim NS, Umezawa Y, Abe N, Yokoyama-Kobayashi M, Aoki T | title = Construction of a human full-length cDNA bank | journal = Gene | volume = 150 | issue = 2 | pages = 243–50 | year = 1995 | pmid = 7821789 | doi = 10.1016/0378-1119(94)90433-2 }}
- {{cite journal | vauthors = Uchiumi T, Kominami R | title = Binding of mammalian ribosomal protein complex P0.P1.P2 and protein L12 to the GTPase-associated domain of 28 S ribosomal RNA and effect on the accessibility to anti-28 S RNA autoantibody | journal = J. Biol. Chem. | volume = 272 | issue = 6 | pages = 3302–8 | year = 1997 | pmid = 9013569 | doi = 10.1074/jbc.272.6.3302 }}
- {{cite journal | vauthors = Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC | title = A map of 75 human ribosomal protein genes | journal = Genome Res. | volume = 8 | issue = 5 | pages = 509–23 | year = 1998 | pmid = 9582194 | doi = 10.1101/gr.8.5.509 }}
- {{cite journal | vauthors = Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI | title = Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry | journal = EMBO J. | volume = 19 | issue = 23 | pages = 6569–81 | year = 2001 | pmid = 11101529 | pmc = 305846 | doi = 10.1093/emboj/19.23.6569 }}
- {{cite journal | vauthors = Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI | title = Directed proteomic analysis of the human nucleolus | journal = Curr. Biol. | volume = 12 | issue = 1 | pages = 1–11 | year = 2002 | pmid = 11790298 | doi = 10.1016/S0960-9822(01)00650-9 }}
- {{cite journal | vauthors = Plafker SM, Macara IG | title = Ribosomal Protein L12 Uses a Distinct Nuclear Import Pathway Mediated by Importin 11 | journal = Mol. Cell. Biol. | volume = 22 | issue = 4 | pages = 1266–75 | year = 2002 | pmid = 11809816 | pmc = 134630 | doi = 10.1128/MCB.22.4.1266-1275.2002 }}
- {{cite journal | vauthors = Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ | title = Immunoaffinity profiling of tyrosine phosphorylation in cancer cells | journal = Nat. Biotechnol. | volume = 23 | issue = 1 | pages = 94–101 | year = 2005 | pmid = 15592455 | doi = 10.1038/nbt1046 }}
- {{cite journal | vauthors = Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M | title = Nucleolar proteome dynamics | journal = Nature | volume = 433 | issue = 7021 | pages = 77–83 | year = 2005 | pmid = 15635413 | doi = 10.1038/nature03207 }}
- {{cite journal | vauthors = Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP | title = A probability-based approach for high-throughput protein phosphorylation analysis and site localization | journal = Nat. Biotechnol. | volume = 24 | issue = 10 | pages = 1285–92 | year = 2006 | pmid = 16964243 | doi = 10.1038/nbt1240 }}
- {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
{{refend}}{{PDB Gallery|geneid=6136}}{{GeneticTranslation}}{{Ribosome subunits}}{{gene-9-stub}} 1 : Ribosomal proteins |