| 释义 |
- Function
- Interactions
- References
- Further reading
{{Infobox_gene}}60S ribosomal protein L13 is a protein that in humans is encoded by the RPL13 gene.[1][2] Function Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L13E family of ribosomal proteins. It is located in the cytoplasm. This gene is expressed at significantly higher levels in benign breast lesions than in breast carcinomas. Transcript variants derived from alternative splicing and/or alternative polyadenylation exist; these variants encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[2] Interactions RPL13 has been shown to interact with CDC5L.[3] References 1. ^{{cite journal | vauthors = Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC | title = A map of 75 human ribosomal protein genes | journal = Genome Res | volume = 8 | issue = 5 | pages = 509–23 | date = August 1998 | pmid = 9582194 | pmc = | doi = 10.1101/gr.8.5.509 }}
2. ^1 {{cite web | title = Entrez Gene: RPL13 ribosomal protein L13| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6137| accessdate = }}
3. ^{{cite journal | vauthors = Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI | title = Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry | journal = EMBO J. | volume = 19 | issue = 23 | pages = 6569–81 | date = December 2000 | pmid = 11101529 | pmc = 305846 | doi = 10.1093/emboj/19.23.6569 }}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Wool IG, Chan YL, Glück A | title = Structure and evolution of mammalian ribosomal proteins. | journal = Biochem. Cell Biol. | volume = 73 | issue = 11–12 | pages = 933–47 | year = 1996 | pmid = 8722009 | doi = 10.1139/o95-101 }}
- {{cite journal | vauthors = Adams SM, Helps NR, Sharp MG, Brammar WJ, Walker RA, Varley JM | title = Isolation and characterization of a novel gene with differential expression in benign and malignant human breast tumours | journal = Hum. Mol. Genet. | volume = 1 | issue = 2 | pages = 91–6 | year = 1993 | pmid = 1301162 | doi = 10.1093/hmg/1.2.91 }}
- {{cite journal | vauthors = Kato S, Sekine S, Oh SW, Kim NS, Umezawa Y, Abe N, Yokoyama-Kobayashi M, Aoki T | title = Construction of a human full-length cDNA bank | journal = Gene | volume = 150 | issue = 2 | pages = 243–50 | year = 1995 | pmid = 7821789 | doi = 10.1016/0378-1119(94)90433-2 }}
- {{cite journal | vauthors = Yaseen NR, Blobel G | title = Cloning and characterization of human karyopherin beta3 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 9 | pages = 4451–6 | year = 1997 | pmid = 9114010 | pmc = 20743 | doi = 10.1073/pnas.94.9.4451 }}
- {{cite journal | vauthors = Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI | title = Directed proteomic analysis of the human nucleolus | journal = Curr. Biol. | volume = 12 | issue = 1 | pages = 1–11 | year = 2002 | pmid = 11790298 | doi = 10.1016/S0960-9822(01)00650-9 }}
- {{cite journal | vauthors = Bi W, Yan J, Stankiewicz P, Park SS, Walz K, Boerkoel CF, Potocki L, Shaffer LG, Devriendt K, Nowaczyk MJ, Inoue K, Lupski JR | title = Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse | journal = Genome Res. | volume = 12 | issue = 5 | pages = 713–28 | year = 2002 | pmid = 11997338 | pmc = 186594 | doi = 10.1101/gr.73702 }}
- {{cite journal | vauthors = Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M | title = Nucleolar proteome dynamics | journal = Nature | volume = 433 | issue = 7021 | pages = 77–83 | year = 2005 | pmid = 15635413 | doi = 10.1038/nature03207 }}
- {{cite journal | vauthors = Kobayashi T, Sasaki Y, Oshima Y, Yamamoto H, Mita H, Suzuki H, Toyota M, Tokino T, Itoh F, Imai K, Shinomura Y | title = Activation of the ribosomal protein L13 gene in human gastrointestinal cancer | journal = Int. J. Mol. Med. | volume = 18 | issue = 1 | pages = 161–70 | year = 2006 | pmid = 16786168 | doi = 10.3892/ijmm.18.1.161 }}
{{refend}}{{GeneticTranslation}}{{Ribosome subunits}}{{gene-16-stub}} 1 : Ribosomal proteins |