| 释义 |
- Function
- Interactions
- References
- External links
- Further reading
{{Infobox_gene}}60S ribosomal protein L14 is a protein that in humans is encoded by the RPL14 gene.[1][2] Function Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L14E family of ribosomal proteins. It contains a basic region-leucine zipper (bZIP)-like domain. The protein is located in the cytoplasm. This gene contains a trinucleotide (GCT) repeat tract whose length is highly polymorphic; these triplet repeats result in a stretch of alanine residues in the encoded protein. Transcript variants utilizing alternative polyA signals and alternative 5'-terminal exons exist but all encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[2] Interactions RPL14 has been shown to interact with PHLDA1.[3] References 1. ^{{cite journal | vauthors = Tanaka M, Tanaka T, Harata M, Suzuki T, Mitsui Y | title = Triplet repeat-containing ribosomal protein L14 gene in immortalized human endothelial cell line (t-HUE4) | journal = Biochem Biophys Res Commun | volume = 243 | issue = 2 | pages = 531–7 | date = March 1998 | pmid = 9480843 | pmc = | doi = 10.1006/bbrc.1998.8125 }}
2. ^1 {{cite web | title = Entrez Gene: RPL14 ribosomal protein L14| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9045| accessdate = }}
3. ^{{cite journal | vauthors = Hinz T, Flindt S, Marx A, Janssen O, Kabelitz D | title = Inhibition of protein synthesis by the T cell receptor-inducible human TDAG51 gene product | journal = Cell. Signal. | volume = 13 | issue = 5 | pages = 345–52 | date = May 2001 | pmid = 11369516 | doi = 10.1016/S0898-6568(01)00141-3 }}
External links Further reading {{refbegin | 2}}- {{cite journal | vauthors = Wool IG, Chan YL, Glück A | title = Structure and evolution of mammalian ribosomal proteins. | journal = Biochem. Cell Biol. | volume = 73 | issue = 11-12 | pages = 933–47 | year = 1996 | pmid = 8722009 | doi = 10.1139/o95-101 }}
- {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
- {{cite journal | vauthors = Dave VP, Larché M, Rencher SD, Koop BF, Hurwitz JL | title = Restricted usage of T-cell receptor V alpha sequence and variable-joining pairs after normal T-cell development and bone marrow transplantation. | journal = Hum. Immunol. | volume = 37 | issue = 3 | pages = 178–84 | year = 1994 | pmid = 8244780 | doi = 10.1016/0198-8859(93)90183-2 }}
- {{cite journal | vauthors = Li SH, McInnis MG, Margolis RL, Antonarakis SE, Ross CA | title = Novel triplet repeat containing genes in human brain: cloning, expression, and length polymorphisms. | journal = Genomics | volume = 16 | issue = 3 | pages = 572–9 | year = 1993 | pmid = 8325628 | doi = 10.1006/geno.1993.1232 }}
- {{cite journal | vauthors = Aoki M, Koranyi L, Riggs AC, Wasson J, Chiu KC, Vaxillaire M, Froguel P, Gough S, Liu L, Donis-Keller H | title = Identification of trinucleotide repeat-containing genes in human pancreatic islets. | journal = Diabetes | volume = 45 | issue = 2 | pages = 157–64 | year = 1996 | pmid = 8549859 | doi = 10.2337/diabetes.45.2.157 }}
- {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
- {{cite journal | vauthors = Reddy PH, Stockburger E, Gillevet P, Tagle DA | title = Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method. | journal = Genomics | volume = 46 | issue = 2 | pages = 174–82 | year = 1998 | pmid = 9417904 | doi = 10.1006/geno.1997.5044 }}
- {{cite journal | vauthors = Hinz T, Flindt S, Marx A, Janssen O, Kabelitz D | title = Inhibition of protein synthesis by the T cell receptor-inducible human TDAG51 gene product. | journal = Cell. Signal. | volume = 13 | issue = 5 | pages = 345–52 | year = 2001 | pmid = 11369516 | doi = 10.1016/S0898-6568(01)00141-3 }}
- {{cite journal | vauthors = Uechi T, Tanaka T, Kenmochi N | title = A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders. | journal = Genomics | volume = 72 | issue = 3 | pages = 223–30 | year = 2001 | pmid = 11401437 | doi = 10.1006/geno.2000.6470 }}
- {{cite journal | vauthors = Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI | title = Directed proteomic analysis of the human nucleolus. | journal = Curr. Biol. | volume = 12 | issue = 1 | pages = 1–11 | year = 2002 | pmid = 11790298 | doi = 10.1016/S0960-9822(01)00650-9 }}
- {{cite journal | vauthors = Yoshihama M, Uechi T, Asakawa S, Kawasaki K, Kato S, Higa S, Maeda N, Minoshima S, Tanaka T, Shimizu N, Kenmochi N | title = The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. | journal = Genome Res. | volume = 12 | issue = 3 | pages = 379–90 | year = 2002 | pmid = 11875025 | pmc = 155282 | doi = 10.1101/gr.214202 }}
- {{cite journal | vauthors = Odintsova TI, Müller EC, Ivanov AV, Egorov TA, Bienert R, Vladimirov SN, Kostka S, Otto A, Wittmann-Liebold B, Karpova GG | title = Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. | journal = J. Protein Chem. | volume = 22 | issue = 3 | pages = 249–58 | year = 2004 | pmid = 12962325 | doi = 10.1023/A:1025068419698 }}
- {{cite journal | vauthors = Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M | title = Nucleolar proteome dynamics. | journal = Nature | volume = 433 | issue = 7021 | pages = 77–83 | year = 2005 | pmid = 15635413 | doi = 10.1038/nature03207 }}
- {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
{{refend}}{{GeneticTranslation}}{{Ribosome subunits}}{{gene-3-stub}} 1 : Ribosomal proteins |