| 释义 |
- Function
- Interactions
- References
- Further reading
{{Infobox_gene}}60S ribosomal protein L7 is a protein that in humans is encoded by the RPL7 gene.[1][2][3] Function Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L30P family of ribosomal proteins. It contains an N-terminal basic region-leucine zipper (BZIP)-like domain and the RNP consensus sub-motif RNP2. In vitro the BZIP-like domain mediates homodimerization and stable binding to DNA and RNA, with a preference for 28S rRNA and mRNA. The protein can inhibit cell-free translation of mRNAs, suggesting that it plays a regulatory role in the translation apparatus. It is located in the cytoplasm. The protein has been shown to be an autoantigen in patients with systemic autoimmune diseases, such as systemic lupus erythematosus. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[3] Interactions RPL7 has been shown to interact with ZNF7.[4] References 1. ^{{cite journal | vauthors = Seshadri T, Uzman JA, Oshima J, Campisi J | title = Identification of a transcript that is down-regulated in senescent human fibroblasts. Cloning, sequence analysis, and regulation of the human L7 ribosomal protein gene | journal = The Journal of Biological Chemistry | volume = 268 | issue = 25 | pages = 18474–80 | date = September 1993 | pmid = 8360149 | pmc = | doi = }}
2. ^{{cite journal | vauthors = Hemmerich P, von Mikecz A, Neumann F, Sözeri O, Wolff-Vorbeck G, Zoebelein R, Krawinkel U | title = Structural and functional properties of ribosomal protein L7 from humans and rodents | journal = Nucleic Acids Research | volume = 21 | issue = 2 | pages = 223–31 | date = January 1993 | pmid = 8441630 | pmc = 309096 | doi = 10.1093/nar/21.2.223 }}
3. ^1 {{cite web | title = Entrez Gene: RPL7 ribosomal protein L7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6129| accessdate = }}
4. ^{{cite journal | vauthors = Witte S, Krawinkel U | title = Specific interactions of the autoantigen L7 with multi-zinc finger protein ZNF7 and ribosomal protein S7 | journal = The Journal of Biological Chemistry | volume = 272 | issue = 35 | pages = 22243–7 | date = August 1997 | pmid = 9268371 | doi = 10.1074/jbc.272.35.22243 }}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Wool IG, Chan YL, Glück A | title = Structure and evolution of mammalian ribosomal proteins | journal = Biochemistry and Cell Biology | volume = 73 | issue = 11-12 | pages = 933–47 | year = 1996 | pmid = 8722009 | doi = 10.1139/o95-101 }}
- {{cite journal | vauthors = von Mikecz A, Hemmerich P, Peter HH, Krawinkel U | title = Characterization of eukaryotic protein L7 as a novel autoantigen which frequently elicits an immune response in patients suffering from systemic autoimmune disease | journal = Immunobiology | volume = 192 | issue = 1-2 | pages = 137–54 | date = December 1994 | pmid = 7750987 | doi = 10.1016/S0171-2985(11)80413-4 }}
- {{cite journal | vauthors = Neumann F, Hemmerich P, von Mikecz A, Peter HH, Krawinkel U | title = Human ribosomal protein L7 inhibits cell-free translation in reticulocyte lysates and affects the expression of nuclear proteins upon stable transfection into Jurkat T-lymphoma cells | journal = Nucleic Acids Research | volume = 23 | issue = 2 | pages = 195–202 | date = January 1995 | pmid = 7862521 | pmc = 306654 | doi = 10.1093/nar/23.2.195 }}
- {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
- {{cite journal | vauthors = Witte S, Krawinkel U | title = Specific interactions of the autoantigen L7 with multi-zinc finger protein ZNF7 and ribosomal protein S7 | journal = The Journal of Biological Chemistry | volume = 272 | issue = 35 | pages = 22243–7 | date = August 1997 | pmid = 9268371 | doi = 10.1074/jbc.272.35.22243 }}
- {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
- {{cite journal | vauthors = Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC | title = A map of 75 human ribosomal protein genes | journal = Genome Research | volume = 8 | issue = 5 | pages = 509–23 | date = May 1998 | pmid = 9582194 | doi = 10.1101/gr.8.5.509 }}
- {{cite journal | vauthors = Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI | title = Directed proteomic analysis of the human nucleolus | journal = Current Biology | volume = 12 | issue = 1 | pages = 1–11 | date = January 2002 | pmid = 11790298 | doi = 10.1016/S0960-9822(01)00650-9 }}
- {{cite journal | vauthors = Brezillon S, Lannoy V, Franssen JD, Le Poul E, Dupriez V, Lucchetti J, Detheux M, Parmentier M | title = Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 2 | pages = 776–83 | date = January 2003 | pmid = 12401809 | doi = 10.1074/jbc.M206396200 }}
- {{cite journal | vauthors = Kasai H, Nadano D, Hidaka E, Higuchi K, Kawakubo M, Sato TA, Nakayama J | title = Differential expression of ribosomal proteins in human normal and neoplastic colorectum | journal = The Journal of Histochemistry and Cytochemistry | volume = 51 | issue = 5 | pages = 567–74 | date = May 2003 | pmid = 12704204 | doi = 10.1177/002215540305100502 }}
- {{cite journal | vauthors = Odintsova TI, Müller EC, Ivanov AV, Egorov TA, Bienert R, Vladimirov SN, Kostka S, Otto A, Wittmann-Liebold B, Karpova GG | title = Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing | journal = Journal of Protein Chemistry | volume = 22 | issue = 3 | pages = 249–58 | date = April 2003 | pmid = 12962325 | doi = 10.1023/A:1025068419698 }}
- {{cite journal | vauthors = Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ | title = Immunoaffinity profiling of tyrosine phosphorylation in cancer cells | journal = Nature Biotechnology | volume = 23 | issue = 1 | pages = 94–101 | date = January 2005 | pmid = 15592455 | doi = 10.1038/nbt1046 }}
- {{cite journal | vauthors = Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M | title = Nucleolar proteome dynamics | journal = Nature | volume = 433 | issue = 7021 | pages = 77–83 | date = January 2005 | pmid = 15635413 | doi = 10.1038/nature03207 }}
- {{cite journal | vauthors = Ko JR, Wu JY, Kirby R, Li IF, Lin A | title = Mapping the essential structures of human ribosomal protein L7 for nuclear entry, ribosome assembly and function | journal = FEBS Letters | volume = 580 | issue = 16 | pages = 3804–10 | date = July 2006 | pmid = 16797011 | doi = 10.1016/j.febslet.2006.05.073 }}
- {{cite journal | vauthors = Wu WC, Liu HW, Lin A | title = Human ribosomal protein L7 displays an ER binding property and is involved in ribosome-ER association | journal = FEBS Letters | volume = 581 | issue = 4 | pages = 651–7 | date = February 2007 | pmid = 17258209 | doi = 10.1016/j.febslet.2007.01.023 }}
{{refend}}{{GeneticTranslation}}{{Ribosome subunits}}{{gene-8-stub}} 1 : Ribosomal proteins |