| 词条 | 6-Br-APB |
| 释义 |
| Verifiedfields = changed | verifiedrevid = 477225692 | IUPAC_name = 3-allyl-6-bromo-1-phenyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol | image = 6BrAPB_structure.png | image2 = 6-Br-APB-3D-balls.png | tradename = | pregnancy_category = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 135974-57-1 | ATC_prefix = | ATC_suffix = | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C19H20BrNO2/c1-2-9-21-10-8-14-15(11-17(22)19(23)18(14)20)16(12-21)13-6-4-3-5-7-13/h2-7,11,16,22-23H,1,8-10,12H2/t16-/m1/s1 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = KKZGFVAZUKHFAC-MRXNPFEDSA-N | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 34095 | PubChem = 11957483 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 8627436 | C=19 | H=20 | Br=1 | N=1 | O=2 | molecular_weight = 374.27 g/mol | smiles = c3ccccc3C2CN(CC=C)CCc(c1Br)c2cc(O)c1O }}6-Br-APB is a synthetic compound that acts as a selective D1 agonist,[1] with the (R)-enantiomer being a potent full agonist, while the (S) enantiomer retains its D1 selectivity but is a weak partial agonist.[2] (R)-6-Br-APB and similar D1-selective full agonists like SKF-81,297 and SKF-82,958 produce characteristic anorectic effects, stereotyped behaviour and self-administration in animals, with a similar but not identical profile to that of dopaminergic stimulants such as amphetamine.[3][4][5] References1. ^{{cite journal |vauthors =Neumeyer JL |title=(+/-)-3-Allyl-6-bromo-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3- benzazepin, a new high-affinity D1 dopamine receptor ligand: synthesis and structure-activity relationship |journal=Journal of Medicinal Chemistry |volume=34 |issue=12 |pages=3366–71 |date=December 1991 |pmid=1684995 |doi= 10.1021/jm00116a004|url=|display-authors=etal}} {{Stimulants}}{{Anorectics}}{{Dopaminergics}}{{gastrointestinal-drug-stub}}2. ^{{cite journal |vauthors =Neumeyer JL, Kula NS, Baldessarini RJ, Baindur N |title=Stereoisomeric probes for the D1 dopamine receptor: synthesis and characterization of R-(+) and S-(-) enantiomers of 3-allyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine and its 6-bromo analogue |journal=Journal of Medicinal Chemistry |volume=35 |issue=8 |pages=1466–71 |date=April 1992 |pmid=1533424 |doi= 10.1021/jm00086a016|url=}} 3. ^{{cite journal |vauthors =Rosenzweig-Lipson S, Hesterberg P, Bergman J |title=Observational studies of dopamine D1 and D2 agonists in squirrel monkeys |journal=Psychopharmacology |volume=116 |issue=1 |pages=9–18 |date=September 1994 |pmid=7862937 |doi= 10.1007/BF02244865|url=}} 4. ^{{cite journal |vauthors =Weed MR, Woolverton WL |title=The reinforcing effects of dopamine D1 receptor agonists in rhesus monkeys |journal=The Journal of Pharmacology and Experimental Therapeutics |volume=275 |issue=3 |pages=1367–74 |date=December 1995 |pmid=8531104 |doi= |url=}} 5. ^{{cite journal |vauthors =Barrett AC, Miller JR, Dohrmann JM, Caine SB |title=Effects of dopamine indirect agonists and selective D1-like and D2-like agonists and antagonists on cocaine self-administration and food maintained responding in rats |journal=Neuropharmacology |volume=47 Suppl 1 |issue= |pages=256–73 |year=2004 |pmid=15464142 |doi=10.1016/j.neuropharm.2004.07.007 |url=}} 4 : Benzazepines|Dopamine agonists|Bromoarenes|Allyl compounds |
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