| 词条 | 7,12-Dimethylbenz(a)anthracene |
| 释义 |
| Watchedfields = changed | Name=7,12-Dimethylbenz[a]anthracene | verifiedrevid = 477226290 | Reference=[1] | ImageFile1=DMBA.png | ImageFile2=7,12-Dimethylbenz(a)anthracene_ballstick.png | PIN = 7,12-Dimethyltetraphene | OtherNames = 7,12-Dimethylbenzo[a]phenanthrene 7,12-Dimethylbenzanthracene 7,12-Dimethyltetraphene 1,4-Dimethyl-2,3-benzophenanthrene |Section1={{Chembox Identifiers | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 5779 | InChI = 1/C20H16/c1-13-16-8-5-6-9-17(16)14(2)20-18(13)12-11-15-7-3-4-10-19(15)20/h3-12H,1-2H3 | InChIKey = ARSRBNBHOADGJU-UHFFFAOYAX | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 329673 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C20H16/c1-13-16-8-5-6-9-17(16)14(2)20-18(13)12-11-15-7-3-4-10-19(15)20/h3-12H,1-2H3 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = ARSRBNBHOADGJU-UHFFFAOYSA-N | CASNo=57-97-6 | CASNo_Ref = {{cascite|correct|CAS}} | PubChem=6001 | ChEBI_Ref = {{ebicite|correct|EBI}} | ChEBI = 254496 | SMILES = c32c(c1ccccc1c(c2ccc4c3cccc4)C)C }} |Section2={{Chembox Properties | C=20 | H=16 | Appearance= | Density= | MeltingPtC=122 to 123 | BoilingPt= | Solubility= |Section3={{Chembox Hazards | MainHazards=T (Toxic) | FlashPt= | AutoignitionPt = | RPhrases={{R45}} {{R22}} | SPhrases={{S53}} {{S36/37}} {{S45}} | NFPA-H = 2 | NFPA-R = 0 | NFPA-F = 0 | NFPA-S = }} 7,12-Dimethylbenz[a]anthracene (DMBA) is an immunosuppressor and a powerful organ-specific laboratory carcinogen.[2] DMBA is widely used in many research laboratories studying cancer. DMBA serves as a tumor initiator. Tumor promotion can be induced with treatments of 12-O-tetradecanoylphorbol-13-acetate (TPA) in some models of two-stage carcinogenesis.[3] This allows for a greatly accelerated rate of tumor growth, making many cancer studies possible. References1. ^7,12-Dimethylbenz(a)anthracene at Sigma-Aldrich 2. ^{{cite journal |author=Miyata M |author2=Furukawa M |author3=Takahashi K |author4=Gonzalez FJ |author5=Yamazoe Y |title=Mechanism of 7, 12-Dimethylbenz[a]anthracene-Induced Immunotoxicity: Role of Metabolic Activation at the Target Organ |journal=Jpn J Pharmacol |date=2001 |volume=86 |pages=302–309 |url=http://sciencelinks.jp/j-east/article/200201/000020020101A0826695.php |doi=10.1254/jjp.86.302 |deadurl=yes |archiveurl=https://web.archive.org/web/20100117042118/http://sciencelinks.jp/j-east/article/200201/000020020101A0826695.php |archivedate=2010-01-17 |df= }} 3. ^{{cite journal | author = Sung YM | author2 = He G | author3 = Fischer, SM | date = 2005 | title = Lack of Expression of the EP2 but not EP3 Receptor for Prostaglandin E2 Results in Suppression of Skin Tumor Development | journal = Cancer Res | volume = 65 | pages = 9304–9311 | doi=10.1158/0008-5472.can-05-1015}} 4 : Polycyclic aromatic hydrocarbons|Carcinogens|Anthracenes|Immunosuppressants |
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