| 词条 | 7-Methyl-α-ethyltryptamine |
| 释义 |
| IUPAC_name = 1-(7-methyl-1H-indol-3-yl)butan-2-amine | image = 7-Methyl-AET.png | width = 240 | CAS_number = 13712-80-6 | CAS_supplemental = freebase 13518-76-8 hydrochloride salt | ATC_prefix = | ATC_suffix = | PubChem = | C=13 | H=18 | N=2 | molecular_weight = 202.295 g/mol | ChemSpiderID = 26286844 | smiles = CCC(N)CC1=CNC2=C(C)C=CC=C21 | StdInChI = 1S/C13H18N2/c1-3-11(14)7-10-8-15-13-9(2)5-4-6-12(10)13/h4-6,8,11,15H,3,7,14H2,1-2H3 | StdInChIKey = NBLFITFQOPGXLS-UHFFFAOYSA-N | melting_point = | melting_high = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = }} 7-Methyl-α-ethyltryptamine (7-Me-αET) is a tryptamine derivative related to α-ethyltryptamine (αET). It was discovered by a team at Upjohn in the early 1960s.[1] It has similar pharmacological effects to αET, but is both 3-4 times more potent as a serotonin releasing agent, and 10 times more potent as a monoamine oxidase inhibitor,[2][3] making it potentially hazardous as this pharmacological profile is shared with drugs such as PMA and 4-MTA, which are known to be dangerous in humans when used at high doses. See also
References1. ^{{US Patent |3296072}} {{Serotonergics}}{{Tryptamines}}{{DEFAULTSORT:Methyl-alpha-ethyltryptamine, 7-}}{{nervous-system-drug-stub}}2. ^{{cite journal | doi =10.1021/jm00333a006 | title =Enzyme Inhibitory Activity of 3-(2-Aminobutyl)indole Derivatives | year =1964 | last1 =Hester | first1 =J. B. | last2 =Greig | first2 =M. E. | last3 =Anthony | first3 =W. C. | last4 =Heinzelman | first4 =R. V. | last5 =Szmuszkovicz | first5 =J. | journal =Journal of Medicinal Chemistry | volume =7 | issue =3 | pages =274}} 3. ^{{cite journal |author =Burningham RA |author2 =Arimura GK |author3 =Yunis AA |title=Effect of Monase and related compounds on uptake of 5-hydroxytryptamine by platelets |journal=Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine |volume=122 |issue=3 |pages=711–4 |date=July 1966 |pmid=5918937 |doi= 10.3181/00379727-122-31233|url=}} 4 : Monoamine oxidase inhibitors|Serotonin receptor agonists|Serotonin-norepinephrine-dopamine releasing agents|Tryptamines |
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