A135, A.135 or A-135 may refer to:

• A-135 anti-ballistic missile system, a Russian military complex deployed around Moscow to counter enemy missiles targeting the city
• A135 road (England), a road in Teesside connecting Stockton-on-Tees and Yarm
• Austin A135, a 1947 British luxury car
• RFA Argus (A135), a 1984 Royal Fleet Auxiliary aviation training ship

• Cole M. Greif-Neill
• Colemill Panther
• Colemin
• Cole Mitchell Sprouse
• Colen Fitzgibbon
• Colensoa
• Colenso controversy
• Colenso, William
• Colentina A.C. Bucuresti
• Colentina Bucureşti
• Colentina București
• Colentina river
• Coleny Hatch Asylum
• Coleocarya
• Coleocarya gracilis
• Coleochloa
• Coleocoma centaurea
• Coleocornutia
• Coleocornutia shirazella
• Coleodactylus amazonicus
• Coleoids
• Coleolid
• Coleolissus
• Coleomethia
• Coleomethia australis