| 词条 | A-372159 |
| 释义 |
| verifiedrevid = 399345932 | IUPAC_name = (8aS,12aR)-2-(4-isopropoxy-2-(trifluoromethyl)phenyl)-6,7,8a,9,10,11,12,12a-octahydro-5H-[1,4]oxazepino[2,3,4-hi]pyrido[4,3-b]indole | image = A-372,159_structure.png | width = 220 | tradename = | legal_status = | routes_of_administration = | metabolism = | elimination_half-life = | excretion = | CAS_number = 313543-60-1 | PubChem = | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 9605283 | C=24 | H=27 | F=3 | N=2 | O=2 | molecular_weight = 432.478 g/mol | smiles = FC(F)(C1=C(C2=CC3=C4C(OCCCN4[C@@]5([H])CCNC[C@@]35[H])=C2)C=CC(OC(C)C)=C1)F | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C24H27F3N2O2/c1-14(2)31-16-4-5-17(20(12-16)24(25,26)27)15-10-18-19-13-28-7-6-21(19)29-8-3-9-30-22(11-15)23(18)29/h4-5,10-12,14,19,21,28H,3,6-9,13H2,1-2H3/t19-,21-/m0/s1 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = LADKOBQJOCFCQU-FPOVZHCZSA-N }}A-372159 is a drug which acts as a potent and selective partial agonist for the 5HT2C receptor, with more than 100x selectivity over the closely related 5-HT2B receptor and a Ki of 3nM. It has been found to produce anorectic effects in animal studies and produced significant weight loss in rats with no development of tolerance or serious side effects.[1] References1. ^Childers WE, Robichaud AJ. Recent Advances in Selective Serotonergic Agents. Annual Reports in Medicinal Chemistry 2005; Volume 40:17-33. {{ISBN|978-0-12-040540-4}} {{Serotonergics}}{{nervous-system-drug-stub}} 6 : Serotonin receptor agonists|Phenol ethers|Trifluoromethyl compounds|Nitrogen heterocycles|Oxygen heterocycles|Isopropyl compounds |
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