| 释义 |
- Function
- References
- Further reading
- External links
{{Infobox_gene}}Adaptor-associated protein kinase 1 also known as AP2-associated protein kinase 1 is an enzyme that in humans is encoded by the AAK1 gene.[1][2][3] Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[3] Function Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit endocytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin.[3] References 1. ^{{cite journal | vauthors = Conner SD, Schmid SL | title = Identification of an adaptor-associated kinase, AAK1, as a regulator of clathrin-mediated endocytosis | journal = The Journal of Cell Biology | volume = 156 | issue = 5 | pages = 921–9 | date = Mar 2002 | pmid = 11877461 | pmc = 2173317 | doi = 10.1083/jcb.200108123 }}
2. ^{{cite journal | vauthors = Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S | title = The protein kinase complement of the human genome | journal = Science | volume = 298 | issue = 5600 | pages = 1912–34 | date = Dec 2002 | pmid = 12471243 | pmc = | doi = 10.1126/science.1075762 }}
3. ^1 2 {{cite web | title = Entrez Gene: AAK1 AP2 associated kinase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22848| accessdate = }}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 6 | issue = 3 | pages = 197–205 | date = Jun 1999 | pmid = 10470851 | doi = 10.1093/dnares/6.3.197 }}
- {{cite journal | vauthors = Ricotta D, Conner SD, Schmid SL, von Figura K, Honing S | title = Phosphorylation of the AP2 mu subunit by AAK1 mediates high affinity binding to membrane protein sorting signals | journal = The Journal of Cell Biology | volume = 156 | issue = 5 | pages = 791–5 | date = Mar 2002 | pmid = 11877457 | pmc = 2173304 | doi = 10.1083/jcb.200111068 }}
- {{cite journal | vauthors = Conner SD, Schmid SL | title = Differential requirements for AP-2 in clathrin-mediated endocytosis | journal = The Journal of Cell Biology | volume = 162 | issue = 5 | pages = 773–9 | date = Sep 2003 | pmid = 12952931 | pmc = 2172816 | doi = 10.1083/jcb.200304069 }}
- {{cite journal | vauthors = Conner SD, Schröter T, Schmid SL | title = AAK1-mediated micro2 phosphorylation is stimulated by assembled clathrin | journal = Traffic | volume = 4 | issue = 12 | pages = 885–90 | date = Dec 2003 | pmid = 14617351 | doi = 10.1046/j.1398-9219.2003.0142.x }}
- {{cite journal | vauthors = Mishra SK, Hawryluk MJ, Brett TJ, Keyel PA, Dupin AL, Jha A, Heuser JE, Fremont DH, Traub LM | title = Dual engagement regulation of protein interactions with the AP-2 adaptor alpha appendage | journal = The Journal of Biological Chemistry | volume = 279 | issue = 44 | pages = 46191–203 | date = Oct 2004 | pmid = 15292237 | doi = 10.1074/jbc.M408095200 }}
- {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–5 | date = Aug 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
- {{cite journal | vauthors = Kim JE, Tannenbaum SR, White FM | title = Global phosphoproteome of HT-29 human colon adenocarcinoma cells | journal = Journal of Proteome Research | volume = 4 | issue = 4 | pages = 1339–46 | year = 2005 | pmid = 16083285 | doi = 10.1021/pr050048h }}
- {{cite journal | vauthors = Collawn JF | title = Unlocking the mysteries of Na+-K+-ATPase endocytosis: phosphorylation is the key | journal = American Journal of Respiratory Cell and Molecular Biology | volume = 35 | issue = 1 | pages = 1–2 | date = Jul 2006 | pmid = 16782842 | pmc = 2658690 | doi = 10.1165/rcmb.f317 }}
- {{cite journal | vauthors = Schmid EM, Ford MG, Burtey A, Praefcke GJ, Peak-Chew SY, Mills IG, Benmerah A, McMahon HT | title = Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly | journal = PLoS Biology | volume = 4 | issue = 9 | pages = e262 | date = Sep 2006 | pmid = 16903783 | pmc = 1540706 | doi = 10.1371/journal.pbio.0040262 }}
- {{cite journal | vauthors = Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP | title = A probability-based approach for high-throughput protein phosphorylation analysis and site localization | journal = Nature Biotechnology | volume = 24 | issue = 10 | pages = 1285–92 | date = Oct 2006 | pmid = 16964243 | doi = 10.1038/nbt1240 }}
- {{cite journal | vauthors = Takahashi T, Furuchi T, Naganuma A | title = Endocytic Ark/Prk kinases play a critical role in adriamycin resistance in both yeast and mammalian cells | journal = Cancer Research | volume = 66 | issue = 24 | pages = 11932–7 | date = Dec 2006 | pmid = 17178891 | doi = 10.1158/0008-5472.CAN-06-3220 }}
- {{cite journal | vauthors = Henderson DM, Conner SD | title = A novel AAK1 splice variant functions at multiple steps of the endocytic pathway | journal = Molecular Biology of the Cell | volume = 18 | issue = 7 | pages = 2698–706 | date = Jul 2007 | pmid = 17494869 | pmc = 1924820 | doi = 10.1091/mbc.E06-09-0831 }}
{{refend}} External links - {{UCSC genome browser|AAK1}}
- {{UCSC gene details|AAK1}}
{{gene-2-stub}}{{DEFAULTSORT:Aak1}} |