| 释义 |
- Function
- References
- External links
- Further reading
{{Infobox_gene}}Multidrug resistance-associated protein 9 is a protein that in humans is encoded by the ABCC12 gene.[1][2][3] Function This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with breast cancer.[3] References1. ^{{cite journal |vauthors=Dean M, Rzhetsky A, Allikmets R | title = The human ATP-binding cassette (ABC) transporter superfamily | journal = Genome Res | volume = 11 | issue = 7 | pages = 1156–66 |date=Jul 2001 | pmid = 11435397 | pmc = | doi = 10.1101/gr.184901 }}
2. ^{{cite journal |vauthors=Tammur J, Prades C, Arnould I, Rzhetsky A, Hutchinson A, Adachi M, Schuetz JD, Swoboda KJ, Ptacek LJ, Rosier M, Dean M, Allikmets R | title = Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12 | journal = Gene | volume = 273 | issue = 1 | pages = 89–96 |date=Aug 2001 | pmid = 11483364 | pmc = | doi =10.1016/S0378-1119(01)00572-8 }}
3. ^1 {{cite web | title = Entrez Gene: ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=94160| accessdate = }}
External links- {{UCSC gene info|ABCC12}}
Adding link to ABCC12 gene details page and display in UCSC genome browser. Further reading{{refbegin | 2}}- {{cite journal |vauthors=Haimeur A, Conseil G, Deeley RG, Cole SP |title=The MRP-related and BCRP/ABCG2 multidrug resistance proteins: biology, substrate specificity and regulation. |journal=Curr. Drug Metab. |volume=5 |issue= 1 |pages= 21–53 |year= 2004 |pmid= 14965249 |doi=10.2174/1389200043489199 }}
- {{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |display-authors=etal}}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{Cite journal | author = Mammalian Gene Collection Program Team | display-authors = 4 | last2 = Strausberg | first2 = R. L. | last3 = Feingold | first3 = E. A. | last4 = Grouse | first4 = L. H. | last5 = Derge | first5 = J. G. | last6 = Klausner | first6 = R. D. | last7 = Collins | first7 = F. S. | last8 = Wagner | first8 = L. | last9 = Shenmen | first9 = C. M. | last10 = Schuler | first10 = G. D. | doi = 10.1073/pnas.242603899 | title = Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences | journal = Proceedings of the National Academy of Sciences | volume = 99 | issue = 26 | pages = 16899–16903 | pmc = 139241 | year = 2002 | pmid = 12477932}}
- {{cite journal |vauthors=Bera TK, Iavarone C, Kumar V |title=MRP9, an unusual truncated member of the ABC transporter superfamily, is highly expressed in breast cancer |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 10 |pages= 6997–7002 |year= 2002 |pmid= 12011458 |doi= 10.1073/pnas.102187299 | pmc=124517 |display-authors=etal}}
- {{cite journal |vauthors=Yabuuchi H, Shimizu H, Takayanagi S, Ishikawa T |title=Multiple splicing variants of two new human ATP-binding cassette transporters, ABCC11 and ABCC12 |journal=Biochem. Biophys. Res. Commun. |volume=288 |issue= 4 |pages= 933–9 |year= 2001 |pmid= 11688999 |doi= 10.1006/bbrc.2001.5865 }}
{{refend}}{{DEFAULTSORT:Abcc12}}{{gene-16-stub}} |