“ABCC3”的意思、由来-开放百科全书

Function

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.^[3]

ABCC3 is induced as a hepatoprotective response to a variety of pathologic liver conditions. The constitutive androstane receptor, pregnane X receptor and nuclear factor (erythroid-derived 2)-like 2 (Nrf2) transcription factors are involved in mediating induction. A functional antioxidant response element in the 8th intron of the human ABCC3 gene appears responsible for Nrf2-mediated induction in response to oxidative stress.^[4]

Interactive pathway map

Further reading

{{cite journal | vauthors = Kool M, de Haas M, Scheffer GL, Scheper RJ, van Eijk MJ, Juijn JA, Baas F, Borst P | title = Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. | journal = Cancer Res. | volume = 57 | issue = 16 | pages = 3537–47 | year = 1997 | pmid = 9270026 | doi = }}

{{cite journal | vauthors = Kiuchi Y, Suzuki H, Hirohashi T, Tyson CA, Sugiyama Y | title = cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3). | journal = FEBS Lett. | volume = 433 | issue = 1–2 | pages = 149–52 | year = 1998 | pmid = 9738950 | doi = 10.1016/S0014-5793(98)00899-0 }}

{{cite journal | vauthors = Uchiumi T, Hinoshita E, Haga S, Nakamura T, Tanaka T, Toh S, Furukawa M, Kawabe T, Wada M, Kagotani K, Okumura K, Kohno K, Akiyama S, Kuwano M | title = Isolation of a novel human canalicular multispecific organic anion transporter, cMOAT2/MRP3, and its expression in cisplatin-resistant cancer cells with decreased ATP-dependent drug transport | journal = Biochem. Biophys. Res. Commun. | volume = 252 | issue = 1 | pages = 103–10 | year = 1998 | pmid = 9813153 | doi = 10.1006/bbrc.1998.9546 }}

{{cite journal | vauthors = Fromm MF, Leake B, Roden DM, Wilkinson GR, Kim RB | title = Human MRP3 transporter: identification of the 5'-flanking region, genomic organization and alternative splice variants | journal = Biochim. Biophys. Acta | volume = 1415 | issue = 2 | pages = 369–74 | year = 1999 | pmid = 9889399 | doi = 10.1016/S0005-2736(98)00233-8 }}

{{cite journal | vauthors = König J, Rost D, Cui Y, Keppler D | title = Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane | journal = Hepatology | volume = 29 | issue = 4 | pages = 1156–63 | year = 1999 | pmid = 10094960 | doi = 10.1002/hep.510290404 }}

{{cite journal | vauthors = Cole SP | title = Re: Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins | journal = J. Natl. Cancer Inst. | volume = 91 | issue = 10 | pages = 888–9 | year = 1999 | pmid = 10340910 | doi = 10.1093/jnci/91.10.888 }}

{{cite journal | vauthors = Kool M, van der Linden M, de Haas M, Scheffer GL, de Vree JM, Smith AJ, Jansen G, Peters GJ, Ponne N, Scheper RJ, Elferink RP, Baas F, Borst P | title = MRP3, an organic anion transporter able to transport anti-cancer drugs | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 12 | pages = 6914–9 | year = 1999 | pmid = 10359813 | pmc = 22016 | doi = 10.1073/pnas.96.12.6914 }}

{{cite journal | vauthors = Ortiz DF, Li S, Iyer R, Zhang X, Novikoff P, Arias IM | title = MRP3, a new ATP-binding cassette protein localized to the canalicular domain of the hepatocyte | journal = Am. J. Physiol. | volume = 276 | issue = 6 Pt 1 | pages = G1493–500 | year = 1999 | pmid = 10362653 | doi = 10.1152/ajpgi.1999.276.6.G1493}}

{{cite journal | vauthors = Takada T, Suzuki H, Sugiyama Y | title = Characterization of 5'-flanking region of human MRP3 | journal = Biochem. Biophys. Res. Commun. | volume = 270 | issue = 3 | pages = 728–32 | year = 2000 | pmid = 10772892 | doi = 10.1006/bbrc.2000.2507 }}

{{cite journal | vauthors = Nies AT, König J, Pfannschmidt M, Klar E, Hofmann WJ, Keppler D | title = Expression of the multidrug resistance proteins MRP2 and MRP3 in human hepatocellular carcinoma | journal = Int. J. Cancer | volume = 94 | issue = 4 | pages = 492–9 | year = 2002 | pmid = 11745434 | doi = 10.1002/ijc.1498 }}

{{cite journal | vauthors = Tatebe S, Sinicrope FA, Kuo MT | title = Induction of multidrug resistance proteins MRP1 and MRP3 and gamma-glutamylcysteine synthetase gene expression by nonsteroidal anti-inflammatory drugs in human colon cancer cells | journal = Biochem. Biophys. Res. Commun. | volume = 290 | issue = 5 | pages = 1427–33 | year = 2002 | pmid = 11820781 | doi = 10.1006/bbrc.2002.6367 }}

{{cite journal | vauthors = Scheffer GL, Kool M, de Haas M, de Vree JM, Pijnenborg AC, Bosman DK, Elferink RP, van der Valk P, Borst P, Scheper RJ | title = Tissue distribution and induction of human multidrug resistant protein 3 | journal = Lab. Invest. | volume = 82 | issue = 2 | pages = 193–201 | year = 2002 | pmid = 11850532 | doi = 10.1038/labinvest.3780411 }}

{{cite journal | vauthors = Zelcer N, Saeki T, Bot I, Kuil A, Borst P | title = Transport of bile acids in multidrug-resistance-protein 3-overexpressing cells co-transfected with the ileal Na+-dependent bile-acid transporter | journal = Biochem. J. | volume = 369 | issue = Pt 1 | pages = 23–30 | year = 2003 | pmid = 12220224 | pmc = 1223054 | doi = 10.1042/BJ20021081 }}

{{cite journal | vauthors = Hooijberg JH, Peters GJ, Assaraf YG, Kathmann I, Priest DG, Bunni MA, Veerman AJ, Scheffer GL, Kaspers GJ, Jansen G | title = The role of multidrug resistance proteins MRP1, MRP2 and MRP3 in cellular folate homeostasis | journal = Biochem. Pharmacol. | volume = 65 | issue = 5 | pages = 765–71 | year = 2003 | pmid = 12628490 | doi = 10.1016/S0006-2952(02)01615-5 }}

{{cite journal | vauthors = Bodo A, Bakos E, Szeri F, Varadi A, Sarkadi B | title = Differential modulation of the human liver conjugate transporters MRP2 and MRP3 by bile acids and organic anions | journal = J. Biol. Chem. | volume = 278 | issue = 26 | pages = 23529–37 | year = 2003 | pmid = 12704183 | doi = 10.1074/jbc.M303515200 }}

{{cite journal | vauthors = Hillman RT, Green RE, Brenner SE | title = An unappreciated role for RNA surveillance | journal = Genome Biol. | volume = 5 | issue = 2 | pages = R8 | year = 2005 | pmid = 14759258 | pmc = 395752 | doi = 10.1186/gb-2004-5-2-r8 }}

{{cite journal | vauthors = Lang T, Hitzl M, Burk O, Mornhinweg E, Keil A, Kerb R, Klein K, Zanger UM, Eichelbaum M, Fromm MF | title = Genetic polymorphisms in the multidrug resistance-associated protein 3 (ABCC3, MRP3) gene and relationship to its mRNA and protein expression in human liver | journal = Pharmacogenetics | volume = 14 | issue = 3 | pages = 155–64 | year = 2004 | pmid = 15167703 | doi = 10.1097/00008571-200403000-00003 }}

Function

Interactive pathway map

See also

References

Further reading

External links