| 词条 | ABT-724 |
| 释义 |
| Verifiedfields = changed | verifiedrevid = 477235138 | IUPAC_name = 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole | image = ABT-724_structure.png | tradename = | licence_EU = | pregnancy_category = | legal_UK = | routes_of_administration = | bioavailability = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 70006-24-5 | ATC_suffix = | UNII_Ref = {{fdacite|changed|FDA}} | UNII = 4WV2575JWT | PubChem = 5025739 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 4204515 | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 440687 | C=17 | H=19 | N=5 | molecular_weight = 293.366 g/mol | smiles = n2c1ccccc1[nH]c2CN(CC4)CCN4c3ncccc3 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C17H19N5/c1-2-6-15-14(5-1)19-16(20-15)13-21-9-11-22(12-10-21)17-7-3-4-8-18-17/h1-8H,9-13H2,(H,19,20) | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = FRPJGTNLZNXQEX-UHFFFAOYSA-N }}ABT-724 is a drug which acts as a dopamine agonist, and is selective for the D4 subtype.[1] It was developed as a possible drug for the treatment of erectile dysfunction,[2] although poor oral bioavailability means alternative drugs such as ABT-670 may be more likely to be developed commercially.[3] Nonetheless, it continues to be used in scientific research into the function of the D4 receptor.[4][5] See also
References1. ^{{cite journal |vauthors=Brioni JD, Moreland RB, Cowart M, Hsieh GC, Stewart AO, Hedlund P, Donnelly-Roberts DL, Nakane M, Lynch JJ, Kolasa T, Polakowski JS, Osinski MA, Marsh K, Andersson KE, Sullivan JP |title=Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats |journal=Proceedings of the National Academy of Sciences of the United States of America |volume=101 |issue=17 |pages=6758–63 |date=April 2004 |pmid=15087502 |pmc=404118 |doi=10.1073/pnas.0308292101 |url=}} {{Drugs for erectile dysfunction and PE}}{{Dopaminergics}}{{DEFAULTSORT:Abt-724}}{{genito-urinary-drug-stub}}2. ^{{cite journal |vauthors=Cowart M, Latshaw SP, Bhatia P, Daanen JF, Rohde J, Nelson SL, Patel M, Kolasa T, Nakane M, Uchic ME, Miller LN, Terranova MA, Chang R, Donnelly-Roberts DL, Namovic MT, Hollingsworth PR, Martino BR, Lynch JJ, Sullivan JP, Hsieh GC, Moreland RB, Brioni JD, Stewart AO |title=Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction |journal=Journal of Medicinal Chemistry |volume=47 |issue=15 |pages=3853–64 |date=July 2004 |pmid=15239663 |doi=10.1021/jm030505a |url=}} 3. ^{{cite journal |vauthors=Patel MV, Kolasa T, Mortell K, Matulenko MA, Hakeem AA, Rohde JJ, Nelson SL, Cowart MD, Nakane M, Miller LN, Uchic ME, Terranova MA, El-Kouhen OF, Donnelly-Roberts DL, Namovic MT, Hollingsworth PR, Chang R, Martino BR, Wetter JM, Marsh KC, Martin R, Darbyshire JF, Gintant G, Hsieh GC, Moreland RB, Sullivan JP, Brioni JD, Stewart AO |title=Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction |journal=Journal of Medicinal Chemistry |volume=49 |issue=25 |pages=7450–65 |date=December 2006 |pmid=17149874 |doi=10.1021/jm060662k |url=}} 4. ^{{cite journal |vauthors=Newman-Tancredi A, Heusler P, Martel JC, Ormière AM, Leduc N, Cussac D |title=Agonist and antagonist properties of antipsychotics at human dopamine D4.4 receptors: G-protein activation and K+ channel modulation in transfected cells |journal=The International Journal of Neuropsychopharmacology |volume=11 |issue=3 |pages=293–307 |date=May 2008 |pmid=17897483 |doi=10.1017/S1461145707008061 |url=}} 5. ^{{cite journal |vauthors=Marona-Lewicka D, Chemel BR, Nichols DE |title=Dopamine D4 receptor involvement in the discriminative stimulus effects in rats of LSD, but not the phenethylamine hallucinogen DOI |journal=Psychopharmacology |volume=203 |issue=2 |pages=265–77 |date=April 2009 |pmid=18604600 |doi=10.1007/s00213-008-1238-0 |url=}} 4 : Dopamine agonists|Piperazines|Pyridines|Benzimidazoles |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。