“Acetyl-CoA C-acetyltransferase”的意思、由来-开放百科全书

词条

Acetyl-CoA C-acetyltransferase

释义

Isozymes
References
Further reading

{{Distinguish|Acyl-CoA:cholesterol acyltransferase|Acetyl-CoA C-acyltransferase}}{{enzyme
| Name = acetyl-CoA C-acetyltransferase
| EC_number = 2.3.1.9
| CAS_number = 9027-46-7
| IUBMB_EC_number = 2/3/1/9
| GO_code = 0003985
| image = 2WKT.png
| width =
| caption = Crystallographic structure of the tetrameric acetoacetyl-CoA thiolase (EC:2.3.1.9) from the Gram-negative bacterium Z. ramigera.^[1]
}}

In enzymology, an acetyl-CoA C-acetyltransferase ({{EC number|2.3.1.9}}) is an enzyme that catalyzes the chemical reaction

2 acetyl-CoA CoA + acetoacetyl-CoA

Hence, this enzyme has one substrate, acetyl-CoA, and two products, CoA and acetoacetyl-CoA.

Acetyl-CoA C-acetyltransferase belongs to the thiolase family of enzymes.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:acetyl-CoA C-acetyltransferase. Other names in common use include acetoacetyl-CoA thiolase, beta-acetoacetyl coenzyme A thiolase, 2-methylacetoacetyl-CoA thiolase [misleading], 3-oxothiolase, acetyl coenzyme A thiolase, acetyl-CoA acetyltransferase, acetyl-CoA:N-acetyltransferase, and thiolase II. This enzyme participates in 10 metabolic pathways: fatty acid metabolism, synthesis and degradation of ketone bodies, valine, leucine and isoleucine degradation, lysine degradation, tryptophan metabolism, pyruvate metabolism, benzoate degradation via coa ligation, propanoate metabolism, butanoate metabolism, and two-component system - general.

Isozymes

Human genes encoding acetyl-CoA C-acetyltransferases include:

{{infobox protein

Name = acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A Thiolase)

caption =

image =

width =

HGNCid = 93

Symbol = ACAT1

AltSymbols =

EntrezGene = 38

OMIM = 607809

RefSeq = NM_000019

UniProt = P24752

PDB =

ECnumber = 2.3.1.9

Chromosome = 11

Arm = q

Band = 22.3-23.1

LocusSupplementaryData =
}}

{{infobox protein

Name = acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase)

caption =

image =

width =

HGNCid = 94

Symbol = ACAT2

AltSymbols =

EntrezGene = 39

OMIM = 100678

RefSeq = NM_005891

UniProt = Q9BWD1

PDB =

ECnumber = 2.3.1.9

Chromosome = 6

Arm = q

Band = 25.3

LocusSupplementaryData = -q26
}}

References

1. ^{{PDB|2WKT}}; {{cite journal |vauthors=Meriläinen G, Poikela V, Kursula P, Wierenga RK | title = The thiolase reaction mechanism: the importance of Asn316 and His348 for stabilizing the enolate intermediate of the Claisen condensation | journal = Biochemistry | volume = 48 | issue = 46 | pages = 11011–25 |date=November 2009 | pmid = 19842716 | doi = 10.1021/bi901069h | url = | issn = }}

Isozymes

References

Further reading