| 词条 | Acotiamide |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 477240986 | IUPAC_name = N2-[bis(1-Methylethyl)amino]ethyl2[(2-hydroxy-4,5-dimethoxyphenyl)carbonyl]amino1,3-thiazole-4-carboxamide | image = Acotiamide.svg | width = 275 | tradename = Acofide (JP) | pregnancy_category = | legal_US_comment = Currently not FDA approved | legal_status = Rx-only (JP) | routes_of_administration = By mouth (tablets) | bioavailability = | protein_bound = 84.21–85.95% | metabolism = UGT1A8 and 1A9 (major) | elimination_half-life = 10.9–21.7 hours | excretion = Feces (92.7%), urine (5.3%)[1] | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 185106-16-5 | ATC_prefix = None | ATC_suffix = | PubChem = 5282338 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 4445505 | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 2107723 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = D42OWK5383 | KEGG_Ref = {{keggcite|changed|kegg}} | KEGG = D08838 | C=21 | H=30 | N=4 | O=5 | S=1 | molecular_weight = 450.55 g/mol | smiles = O=C(Nc1nc(C(=O)NCCN(C(C)C)C(C)C)cs1)c2cc(OC)c(OC)cc2O | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C21H30N4O5S/c1-12(2)25(13(3)4)8-7-22-20(28)15-11-31-21(23-15)24-19(27)14-9-17(29-5)18(30-6)10-16(14)26/h9-13,26H,7-8H2,1-6H3,(H,22,28)(H,23,24,27) | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = TWHZNAUBXFZMCA-UHFFFAOYSA-N }} Acotiamide (brand name Acofide, codenamed YM-443 and Z-338) is a drug manufactured and approved in Japan for the treatment of postprandial fullness, upper abdominal bloating, and early satiation due to functional dyspepsia.[2] It acts as an acetylcholinesterase inhibitor. It is pending approval in the United States; ten clinical trials have been successfully completed. References1. ^{{cite web|title=Acofide (acotiamide hydrochloride hydrate) Tablets Review Report|url=https://www.pmda.go.jp/files/000153467.pdf|accessdate=29 December 2016}} {{Drugs for functional gastrointestinal disorders}}{{Acetylcholine metabolism and transport modulators}}{{gastrointestinal-drug-stub}}{{amine-stub}}2. ^{{cite journal | last1 = Matsueda | first1 = K | last2 = Hongo | first2 = M | last3 = Tack | first3 = J | last4 = Aoki | first4 = H | last5 = Saito | first5 = Y | last6 = Kato | first6 = H | title = Clinical trial: dose-dependent therapeutic efficacy of acotiamide hydrochloride (Z-338) in patients withfunctional dyspepsia – 100 mg t.i.d. is an optimal dosage | journal = Neurogastroenterology & Motility | date = June 2010 | volume = 22 | issue = 6 | pages = 618–e173 | doi = 10.1111/j.1365-2982.2009.01449.x | pmid = 20059698 }} 7 : Acetylcholinesterase inhibitors|Amines|Phenol ethers|Salicylamides|Thiazoles|Isopropyl compounds|Carboxamides |
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