“Acyl-CoA hydrolase”的意思、由来-开放百科全书

词条

Acyl-CoA hydrolase

释义

Structural studies
References

{{enzyme
| Name = acyl-CoA hydrolase
| EC_number = 3.1.2.20
| CAS_number = 37270-64-7
| IUBMB_EC_number = 3/1/2/20
| GO_code = 0047617
| image =
| width =
| caption =
}}

In enzymology, an acyl-CoA hydrolase ({{EC number|3.1.2.20}}) is an enzyme that catalyzes the chemical reaction

acyl-CoA + H₂O CoA + a carboxylate

Thus, the two substrates of this enzyme are acyl-CoA and H₂O, whereas its two products are CoA and carboxylate.

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is acyl-CoA hydrolase. Other names in common use include acyl coenzyme A thioesterase, acyl-CoA thioesterase, acyl coenzyme A hydrolase, thioesterase B, thioesterase II, and acyl-CoA thioesterase.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1Y7U}} and {{PDB link|2GVH}}.

References

{{cite journal | vauthors = Alexson SE, Svensson LT, Nedergaard J | date = 1989 | title = NADH-sensitive propionyl-CoA hydrolase in brown-adipose-tissue mitochondria of the rat | journal = Biochim. Biophys. Acta | volume = 1005 | pages = 13–9 | pmid = 2570608 | issue = 1 | doi=10.1016/0005-2760(89)90025-8}}

2 : EC 3.1.2|Enzymes of known structure

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