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词条 ADCY9
释义

  1. Function

  2. References

  3. External links

  4. Further reading

{{Infobox_gene}}Adenylyl cyclase type 9 is an enzyme that in humans is encoded by the ADCY9 gene.[1][2]

Function

Adenylyl cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. It is regulated by a family of G protein-coupled receptors, protein kinases, and calcium. The type 9 adenylyl cyclase is a widely distributed adenylyl cyclase, and it is stimulated by beta-adrenergic receptor activation but is insensitive to forskolin, calcium, and somatostatin.[2]

References

1. ^{{cite journal | vauthors = Hacker BM, Tomlinson JE, Wayman GA, Sultana R, Chan G, Villacres E, Disteche C, Storm DR | title = Cloning, chromosomal mapping, and regulatory properties of the human type 9 adenylyl cyclase (ADCY9) | journal = Genomics | volume = 50 | issue = 1 | pages = 97–104 |date=Apr 1999| pmid = 9628827 | pmc = | doi = 10.1006/geno.1998.5293 }}
2. ^{{cite web | title = Entrez Gene: ADCY9 adenylate cyclase 9| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=115| accessdate = }}

External links

  • {{UCSC gene info|ADCY9}}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors=Nakajima D, Okazaki N, Yamakawa H |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=10.1093/dnares/9.3.99 |display-authors=etal}}
  • {{cite journal | vauthors=Paterson JM, Smith SM, Harmar AJ, Antoni FA |title=Control of a novel adenylyl cyclase by calcineurin. |journal=Biochem. Biophys. Res. Commun. |volume=214 |issue= 3 |pages= 1000–8 |year= 1995 |pmid= 7575502 |doi= 10.1006/bbrc.1995.2385 }}
  • {{cite journal | vauthors=Premont RT, Matsuoka I, Mattei MG |title=Identification and characterization of a widely expressed form of adenylyl cyclase. |journal=J. Biol. Chem. |volume=271 |issue= 23 |pages= 13900–7 |year= 1996 |pmid= 8662814 |doi=10.1074/jbc.271.23.13900 |display-authors=etal}}
  • {{cite journal | vauthors=Nagase T, Ishikawa K, Miyajima N |title=Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 1 |pages= 31–9 |year= 1998 |pmid= 9628581 |doi=10.1093/dnares/5.1.31 |display-authors=etal}}
  • {{cite journal | vauthors=Barcova M, Speth C, Kacani L |title=Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1. |journal=Pflügers Arch. |volume=437 |issue= 4 |pages= 538–46 |year= 1999 |pmid= 10089566 |doi=10.1007/s004240050815 |display-authors=etal}}
  • {{cite journal | vauthors=Speth C, Joebstl B, Barcova M, Dierich MP |title=HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones. |journal=AIDS |volume=14 |issue= 6 |pages= 629–36 |year= 2000 |pmid= 10807185 |doi=10.1097/00002030-200004140-00001 }}
  • {{cite journal | vauthors=Patke CL, Shearer WT |title=gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression. |journal=J. Allergy Clin. Immunol. |volume=105 |issue= 5 |pages= 975–82 |year= 2000 |pmid= 10808179 |doi= 10.1067/mai.2000.105315 }}
  • {{cite journal | vauthors=Patrizio M, Colucci M, Levi G |title=Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures. |journal=J. Neurochem. |volume=77 |issue= 2 |pages= 399–407 |year= 2001 |pmid= 11299302 |doi=10.1046/j.1471-4159.2001.00249.x }}
  • {{cite journal | vauthors=Toyota T, Hattori E, Meerabux J |title=Molecular analysis, mutation screening, and association study of adenylate cyclase type 9 gene (ADCY9) in mood disorders. |journal=Am. J. Med. Genet. |volume=114 |issue= 1 |pages= 84–92 |year= 2002 |pmid= 11840511 |doi=10.1002/ajmg.10117 |display-authors=etal}}
  • {{cite journal | vauthors=Speth C, Schabetsberger T, Mohsenipour I |title=Mechanism of Human Immunodeficiency Virus-Induced Complement Expression in Astrocytes and Neurons |journal=J. Virol. |volume=76 |issue= 7 |pages= 3179–88 |year= 2002 |pmid= 11884542 |doi=10.1128/JVI.76.7.3179-3188.2002 | pmc=136041 |display-authors=etal}}
  • {{cite journal | vauthors=Toyota T, Yamada K, Saito K |title=Association analysis of adenylate cyclase type 9 gene using pedigree disequilibrium test in bipolar disorder |journal=Mol. Psychiatry |volume=7 |issue= 5 |pages= 450–2 |year= 2002 |pmid= 12082561 |doi= 10.1038/sj.mp.4000992 |display-authors=etal}}
  • {{cite journal | vauthors=Ludwig MG, Seuwen K |title=Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms |journal=J. Recept. Signal Transduct. Res. |volume=22 |issue= 1–4 |pages= 79–110 |year= 2003 |pmid= 12503609 |doi=10.1081/RRS-120014589 }}
  • {{cite journal | vauthors=Small KM, Brown KM, Theiss CT |title=An Ile to Met polymorphism in the catalytic domain of adenylyl cyclase type 9 confers reduced beta2-adrenergic receptor stimulation |journal=Pharmacogenetics |volume=13 |issue= 9 |pages= 535–41 |year= 2004 |pmid= 12972952 |doi= 10.1097/00008571-200309000-00002 |display-authors=etal}}
  • {{cite journal | vauthors=Cumbay MG, Watts VJ |title=Novel regulatory properties of human type 9 adenylate cyclase |journal=J. Pharmacol. Exp. Ther. |volume=310 |issue= 1 |pages= 108–15 |year= 2004 |pmid= 14996950 |doi= 10.1124/jpet.104.065748 }}
  • {{cite journal | vauthors=Tantisira KG, Small KM, Litonjua AA |title=Molecular properties and pharmacogenetics of a polymorphism of adenylyl cyclase type 9 in asthma: interaction between beta-agonist and corticosteroid pathways |journal=Hum. Mol. Genet. |volume=14 |issue= 12 |pages= 1671–7 |year= 2005 |pmid= 15879435 |doi= 10.1093/hmg/ddi175 |display-authors=etal}}
  • {{cite journal | vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |display-authors=etal}}
  • {{cite journal | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal}}
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2 : Biology of bipolar disorder|EC 4.6.1

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