Afanasy ({{lang-ru|Афана́сий}}) is the Russian form of Athanasios, a Greek name meaning "immortal". It may refer to:

• Afanasy Bagration, Prince Adarnase of Kartli (1707–1784), Georgian prince royal and Russian Empire general
• Afanasy Beloborodov (1903–1990), Russian general
• Afanasy Fet (1820–1892), Russian poet
• Afanasy Grigoriev (1782–1868), Russian architect
• Afanasy Nikitin (died 1472), Russian merchant and traveler
• Afanasy Ordin-Nashchokin (1605–1680), Russian statesman
• Afanasy Razmaritsyn (1844–1917), Russian-Ukrainian painter
• Afanasy Seredin-Sabatin (1860–1921), Russian architect and journalist, first Western architect to live and work in the Korean Empire
• Afanasy Shchapov (1830–1876), Russian historian

• Afanasy Ivanovich Tovstogub, the main character of Nikolai Gogol's short story The Old World Landowners

The surname Afanasyev ({{lang-ru|Афана́сьев}}) is derived from the name. The surname Afonin ({{lang-ru|Афо́нин}}) is derived from Afonya, the short form of the name.

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